Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches

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dc.citation.volume80
dc.contributor.authorCorrea-Velloso, Juliana C.
dc.contributor.authorGoncalves, Maria C. B. [UNIFESP]
dc.contributor.authorNaaldijk, Yahaira
dc.contributor.authorOliveira-Giacomelli, Agatha
dc.contributor.authorPillat, Micheli M.
dc.contributor.authorUlrich, Henning
dc.coverageOxford
dc.date.accessioned2020-07-08T13:09:53Z
dc.date.available2020-07-08T13:09:53Z
dc.date.issued2018
dc.description.abstractNeuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be critical for the progression of those disorders, which are based on genetic and epigenetic mechanisms as well as on extrinsic factors. We review here common mechanisms underlying the comorbidity of Bipolar Disorders and Alzheimer's Disease, such as aberrant neurogenesis and neurotoxicity, reporting current therapeutic approaches. The understanding of these mechanisms precedes stem cell-based strategies as a new therapeutic possibility for treatment and prevention of Bipolar and Alzheimer's Disease progression. Taking into account the difficulty of studying the molecular basis of disease progression directly in patients, we also discuss the importance of stem cells for effective drug screening, modeling and treating psychiatric diseases, once in vitro differentiation of patient-induced pluripotent stem cells provides relevant information about embryonic origins, intracellular pathways and molecular mechanisms.en
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurociencias, Rua Pedro de Toledo 669, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurociencias, Rua Pedro de Toledo 669, BR-04039032 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research State Foundation FAPESP
dc.description.sponsorshipNational Council for Scientific and Technological Development CNPq, Brazil
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDFAPESP: 2012/50880-4
dc.description.sponsorshipIDCNPq: 306429/2013-6
dc.description.sponsorshipIDCNPq: 141979/2014-3, 870458/1997-3
dc.description.sponsorshipIDFAPESP: 2015/19478-3, 2015/14343-2
dc.format.extent34-53
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2017.04.033
dc.identifier.citationProgress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 80, p. 34-53, 2018.
dc.identifier.doi10.1016/j.pnpbp.2017.04.033
dc.identifier.issn0278-5846
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54277
dc.identifier.wosWOS:000414025900006
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBipolar Disorderen
dc.subjectAlzheimer's Diseaseen
dc.subjectStem cell therapyen
dc.subjectLithiumen
dc.subjectMemantineen
dc.titlePathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approachesen
dc.typeinfo:eu-repo/semantics/article
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