Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?

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dc.contributor.authorCalzavara, Mariana Bendlin [UNIFESP]
dc.contributor.authorMedrano, Wladimir Agostini [UNIFESP]
dc.contributor.authorLevin, Raquel [UNIFESP]
dc.contributor.authorKameda, Sonia Regina [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSilva, Regina Helena
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.date.accessioned2016-01-24T13:52:39Z
dc.date.available2016-01-24T13:52:39Z
dc.date.issued2009-07-01
dc.description.abstractSchizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). the aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). the effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. the repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Physiol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent748-759
dc.identifierhttp://dx.doi.org/10.1093/schbul/sbn006
dc.identifier.citationSchizophrenia Bulletin. Oxford: Oxford Univ Press, v. 35, n. 4, p. 748-759, 2009.
dc.identifier.doi10.1093/schbul/sbn006
dc.identifier.issn0586-7614
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31613
dc.identifier.wosWOS:000268241700014
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofSchizophrenia Bulletin
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.subjectratsen
dc.subjectpsychiatric disorderen
dc.subjectemotional memoryen
dc.subjectantipsychoticsen
dc.subjectamphetamineen
dc.subjectmood stabilizersen
dc.titleNeuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?en
dc.typeinfo:eu-repo/semantics/article
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