The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index A Randomized, Double-Blind, Cross-Over Study

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dc.citation.issue11
dc.citation.volume13
dc.contributor.authorLi, Yanru
dc.contributor.authorOwens, Robert L.
dc.contributor.authorSands, Scott
dc.contributor.authorOrr, Jeremy
dc.contributor.authorMoraes, Walter [UNIFESP]
dc.contributor.authorDeYoung, Pamela
dc.contributor.authorSmales, Erik
dc.contributor.authorJen, Rachel
dc.contributor.authorMalhotra, Atul
dc.coverageNew York
dc.date.accessioned2020-07-31T12:47:31Z
dc.date.available2020-07-31T12:47:31Z
dc.date.issued2016
dc.description.abstractRationale: Obstructive sleep apnea (OSA) has multiple pathophysiological causes. A low respiratory arousal threshold (ArTh) and a high loop gain (unstable ventilatory control) can contribute to recurrent respiratory events in patients with OSA. Prior studies have shown that donepezil, an acetylcholinesterase inhibitor, might improve OSA, but the mechanism is unknown. Objectives: To determine whether a single dose of donepezil lowers the apnea-hypopnea index by modulating the ArTh or loop gain. Methods: In this randomized, double-blind, crossover trial, 41 subjects with OSA underwent two polysomnograms with ArTh and loop gain evaluated, during which 10 mg of donepezil or placebo was administered. Measurements and Main Results: Compared with placebo, sleep efficiency (77.2 vs. 71.9%en
dc.description.abstractP = 0.015) and total sleep time decreased with donepezil (372 vs. 351 minen
dc.description.abstractP = 0.004). No differences were found in apnea-hypopnea index (51.8 vs. 50.0 events/hen
dc.description.abstractP = 0.576) or nadir oxygen saturation as determined by pulse oximetry (80.3 vs. 81.1%en
dc.description.abstractP = 0.241) between placebo and donepezil, respectively. ArTh was not significantly changed (-18.9 vs. -18.0 cm H2Oen
dc.description.abstractP = 0.394) with donepezil. As a whole group, loop gain (ventilatory response to a 1-cycle/min disturbance) did not change significantly (P = 0.089). Conclusions: A single dose of donepezil did not appear to affect the overall severity of OSA in this patient group, and no consistent effects on ArTh or loop gain were observed. Donepezil may have minor effects on sleep architecture.en
dc.description.affiliationCapital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
dc.description.affiliationUniv Calif San Diego, Div Pulm & Crit Care Med, 9300 Campus Point Dr,7381, La Jolla, CA 92093 USA
dc.description.affiliationBrigham & Womens Hosp, Div Sleep Med, Boston, MA USA
dc.description.affiliationHarvard Med Sch, Boston, MA USA
dc.description.affiliationImmunol & Resp Med & Cent Clin Sch, Dept Allergy, Alfred, NY USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUniv British Columbia, Div Resp Med, Vancouver, BC, Canada
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.sponsorshipNational Natural Science Foundation of China
dc.description.sponsorshipNational Health and Medical Research Council of Australia Early Career Fellowship
dc.description.sponsorshipR.G. Menzies award
dc.description.sponsorshipAmerican Heart Association
dc.description.sponsorshipIDNIH: RO1 HL085188
dc.description.sponsorshipIDNIH: K24 HL132105
dc.description.sponsorshipIDNIH: R21 HL121794
dc.description.sponsorshipIDNIH: RO1 HL 119201
dc.description.sponsorshipIDNIH: RO1 HL081823
dc.description.sponsorshipIDNational Natural Science Foundation of China: 81200735
dc.description.sponsorshipIDNational Health and Medical Research Council of Australia Early Career Fellowship: 1053201
dc.description.sponsorshipIDAmerican Heart Association: 15SDG25890059
dc.format.extent2012-2018
dc.identifierhttp://dx.doi.org/10.1513/AnnalsATS.201605-384OC
dc.identifier.citationAnnals Of The American Thoracic Society. New York, v. 13, n. 11, p. 2012-2018, 2016.
dc.identifier.doi10.1513/AnnalsATS.201605-384OC
dc.identifier.issn1546-3222
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56876
dc.identifier.wosWOS:000419097900023
dc.language.isoeng
dc.publisherAmer Thoracic Soc
dc.relation.ispartofAnnals Of The American Thoracic Society
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectobstructive sleep apneaen
dc.subjectdonepezilen
dc.subjectarousal thresholden
dc.subjectloop gainen
dc.subjecttreatmenten
dc.titleThe Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index A Randomized, Double-Blind, Cross-Over Studyen
dc.typeinfo:eu-repo/semantics/article
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