Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents

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dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorPrado, Wagner Luiz do [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorCaranti, Danielle Arisa [UNIFESP]
dc.contributor.authorLofrano-Prado, Mara Cristina [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorCristofalo, Dejaldo J. M. [UNIFESP]
dc.contributor.authorLederman, Henrique Manoel [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:32Z
dc.date.available2016-01-24T13:49:32Z
dc.date.issued2008-02-01
dc.description.abstractBackground. Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease. Aims. Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile. Subjects. 181 obese adolescents including 113 girls (16.58 +/- 1.56 years) and 68 boys (16.87 +/- 1.62 years) were evaluated. Methods. the inclusion criteria were obesity and post-pubertal stage of Tanner. Visceral fat of obese adolescents was distributed in quartiles after ultrasound nonalcoholic fatty liver disease diagnosis. Results. Nonalcoholic fatty liver disease prevalence was 45.30%. It was observed that 62.07% and 76.47% of girls and boys with nonalcoholic fatty liver disease were found in the 4th quartile. in a multivariate logistic analysis it was observed that only visceral fat remained statistically significant, every I cm increase in visceral fat was associated with a 1.97 fold (95% CI 1.06-3.66) in boys and 2.08 fold (95% CI 1.38-3.13) in girls increased risk to develop nonalcoholic fatty liver disease. Indeed it was verified a positive correlation between visceral fat, body mass index, insulin levels, homeostasis model assessment insulin resistance index and steatosis degree. Conclusions. Our findings suggested that the expansion of visceral fat was a determinant factor to increase nonalcoholic fatty liver disease prevalence and the visceral fat measured by ultrasound might be a good predictor to identify risk for nonalcoholic fatty liver disease in obese adolescents. It was confirmed by a stronger correlation between visceral fat and body mass index. (c) 2007 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Nutr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Hlth Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, UNIFESP EPM, Dept Hlth Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent132-139
dc.identifierhttps://dx.doi.org/10.1016/j.dld.2007.09.009
dc.identifier.citationDigestive and Liver Disease. Pisa: Pacini Editore, v. 40, n. 2, p. 132-139, 2008.
dc.identifier.doi10.1016/j.dld.2007.09.009
dc.identifier.issn1590-8658
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30412
dc.identifier.wosWOS:000253402800009
dc.language.isoeng
dc.publisherPacini Editore
dc.relation.ispartofDigestive and Liver Disease
dc.rightsAcesso restrito
dc.subjectNonalcoholic fatty liver diseaseen
dc.subjectVisceral faten
dc.titleRelationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescentsen
dc.typeArtigo
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