MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma

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dc.citation.issue11
dc.citation.volume55
dc.contributor.authorGamba, Francine Tesser [UNIFESP]
dc.contributor.authorLopes, Luana Joyce da Silva [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:25Z
dc.date.available2020-07-31T12:47:25Z
dc.date.issued2016
dc.description.abstractOsteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. In our previous study, MAPK7 has been identified as a candidate oncogene, and a promising prognostic marker for OS. Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK) cascades is a common mechanism of signal transduction in many cellular processes. In this study, we investigated the behavior of MAPK7 gene in OS cell lines. Technical viability, proliferation, migration, invasion, and apoptosis were used to evaluate the function of the MAPK7 gene. We evaluated the behavior of the OS cells with MAPK7 gene silenced, not silenced, and exposed to the main chemotherapy drugs used in OS treatment. We found that silenced MAPK7 gene is effective at suppressing cell proliferation, inhibiting cell migration, and invasion. Furthermore, MAPK7 is an important activator of transcription factors and is the main expression modulator of other key genes in the MAPK pathway. In summary, our study suggests that MAPK7 might be a promising therapeutic target for OS. (C) 2015 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Fed Sao Paulo, Pediat Oncol Inst IOP GRAACC, Genet Lab, Dept Pediat, Rua Botucatu 743,8th Floor, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pediat Oncol Inst IOP GRAACC, Genet Lab, Dept Morphol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pediat Oncol Inst IOP GRAACC, Genet Lab, Dept Clin & Expt Oncol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pediat Oncol Inst IOP GRAACC, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Pediatrics, Genetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Universidade Federal de São Paulo (UNIFESP), São Paulo‐SP, Brazil
dc.description.affiliationUnifespDepartment of Morphology and Genetics, Genetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Universidade Federal de São Paulo (UNIFESP), São Paulo‐SP, Brazil
dc.description.affiliationUnifespDepartment of Clinical and Experimental Oncology, Genetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Universidade Federal de São Paulo (UNIFESP), São Paulo‐SP, Brazil
dc.description.affiliationUnifespDepartment of Pediatrics, Pediatric Oncology Institute (IOP/GRAACC), Universidade Federal de São Paulo (UNIFESP), São Paulo‐SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPediatric Oncology Institute IOP-GRAACC/UNIFESP
dc.description.sponsorshipIDFAPESP: 2010/10782-8
dc.description.sponsorshipIDFAPESP: 2011/10459-5
dc.format.extent1700-1713
dc.identifierhttp://dx.doi.org/10.1002/mc.22420
dc.identifier.citationMolecular Carcinogenesis. Hoboken, v. 55, n. 11, p. 1700-1713, 2016.
dc.identifier.doi10.1002/mc.22420
dc.identifier.issn0899-1987
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56814
dc.identifier.wosWOS:000387853200018
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMolecular Carcinogenesis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMAP kinase signaling systemen
dc.subjectosteosarcomaen
dc.subjecttherapeutic targeten
dc.subjectbiological tumor markeren
dc.subjectMAPK7en
dc.titleMAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcomaen
dc.typeinfo:eu-repo/semantics/article
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