Estrogen and Its Receptors in Efferent Ductules and Epididymis

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dc.contributor.authorHess, Rex A.
dc.contributor.authorFernandes, Sheilla Alessandra Ferreira [UNIFESP]
dc.contributor.authorGomes, Gisele Renata de Oliveira [UNIFESP]
dc.contributor.authorOliveira, Cleida A.
dc.contributor.authorLazari, Maria de Fatima Magalhaes [UNIFESP]
dc.contributor.authorPorto, Catarina Segreti [UNIFESP]
dc.contributor.institutionUniv Illinois
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2016-01-24T14:17:21Z
dc.date.available2016-01-24T14:17:21Z
dc.date.issued2011-11-01
dc.description.abstractEstrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive.en
dc.description.affiliationUniv Illinois, Dept Comparat Biosci, Urbana, IL 61802 USA
dc.description.affiliationUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent600-613
dc.identifierhttp://dx.doi.org/10.2164/jandrol.110.012872
dc.identifier.citationJournal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011.
dc.identifier.doi10.2164/jandrol.110.012872
dc.identifier.issn0196-3635
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34172
dc.identifier.wosWOS:000296037400007
dc.language.isoeng
dc.publisherAmer Soc Andrology, Inc
dc.relation.ispartofJournal of Andrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEstrogen receptorsen
dc.subjectGperen
dc.titleEstrogen and Its Receptors in Efferent Ductules and Epididymisen
dc.typeinfo:eu-repo/semantics/article
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