Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

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dc.contributor.authorPiccolomini, Mariana M.
dc.contributor.authorNicolielo, Mariana
dc.contributor.authorBonetti, Tatiana C. S. [UNIFESP]
dc.contributor.authorMotta, Eduardo L. A. [UNIFESP]
dc.contributor.authorSerafini, Paulo C.
dc.contributor.authorAlegretti, Jose Roberto
dc.date.accessioned2019-07-22T15:46:45Z
dc.date.available2019-07-22T15:46:45Z
dc.date.issued2016
dc.description.abstractThe aneuploidy rates in expanded blastocysts biopsied on days 5 and 6 development were assessed in women undergoing IVF followed by array comparative genomic hybridization. This study included 1171 expanded blastocysts from 465 patients. Among the 465 patients, 215 and 141 underwent embryo biopsy on day 5 and day 6 (46.2% and 30.3%, respectively), and 109 underwent biopsy on both days 5 and 6 (23.4%). The cycles of 206 women were cancelled because only aneuploidy embryos were present (44.3%). The aneuploid embryos were classified according to the type as single, double or complex aneuploidy. No differences were observed in the distributions of these three categories according to the day of the biopsy. The aneuploidy rate was also evaluated according to maternal age, and was found to be higher in older patientsen
dc.description.abstracthowever, no differences in this rate were detected between embryos biopsied on days 5 and 6 according to maternal age. Biopsy was carried out when blastocysts reached the expanded stage. The embryos biopsied on day 6 had a higher rate of aneuploidy (69.9%) than those biopsied on day 5 (61.4%)en
dc.description.abstracthowever, the euploid embryos transferred had similar chances for successful and healthy gestation. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationHuntington Med Reprod, Av Republ Libano 529, BR-04501000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP EPM, Escola Paulista Med, Dept Ginecol, Disciplina Ginecol Endocrinol, Rua Napoleao de Barros 608, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Obstet & Ginecol, Disciplina Ginecol, Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP EPM, Escola Paulista Med, Dept Ginecol, Disciplina Ginecol Endocrinol, Rua Napoleao de Barros 608, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent398-403
dc.identifierhttp://dx.doi.org/10.1016/j.rbmo.2016.06.005
dc.identifier.citationReproductive Biomedicine Online. Oxford, v. 33, n. 3, p. 398-403, 2016.
dc.identifier.doi10.1016/j.rbmo.2016.06.005
dc.identifier.issn1472-6483
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51065
dc.identifier.wosWOS:000386589100009
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectarray-CGHen
dc.subjectembryo aneuploidyen
dc.subjectembryo cultureen
dc.subjecttrophectoderm biopsyen
dc.titleDoes slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?en
dc.typeinfo:eu-repo/semantics/article
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