Instability Resistance Training Improves Neuromuscular Outcome in Parkinson's Disease

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dc.citation.issue4
dc.citation.volume49
dc.contributor.authorSilva-Batista, Carla
dc.contributor.authorCorcos, Daniel Montie
dc.contributor.authorBarroso, Renato
dc.contributor.authorDavid, Fabian J.
dc.contributor.authorKanegusuku, Helcio
dc.contributor.authorForjaz, Cláudia Lúcia de Moraes
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorRoschel, Hamilton
dc.contributor.authorTricoli, Valmor
dc.contributor.authorUgrinowitsch, Carlos
dc.coveragePhiladelphia
dc.date.accessioned2020-07-17T14:02:34Z
dc.date.available2020-07-17T14:02:34Z
dc.date.issued2017
dc.description.abstractPurpose: This study compared the effects of resistance training (RT) and RT with instability (RTI) on neuromuscular and total training volume (TTV) outcomes obtained as part of the Instability Resistance Training Trial in Parkinson's disease. It also used a linear multiple regression (forward stepwise method) to identify the contribution of neuromuscular outcomes to previously published improvements in the timed-up-and-go test and the Unified Parkinson's Disease Rating Scale, motor subscale score. Methods: Thirty-nine patients with moderate to severe Parkinson's disease were randomly assigned to three groups: control (C), RT, and RTI. RT and RTI groups performed resistance exercises twice a week for 12 wk, and only the RTI group used unstable devices to perform resistance exercises. The following neuromuscular outcomes were assessed: quadriceps muscle cross-sectional area, root mean square and mean spike frequency of electromyographic signal, peak torque, rate of torque development, and half relaxation time of the knee extensors and plantarflexors during maximum ballistic voluntary isometric contractions. TTV was calculated for lower limb exercises. Results: From pre-to posttraining, RTI improved all of the neuromuscular outcomes (P < 0.05) except half relaxation time of the knee extensors (P = 0.068), despite the lower TTV than RT (P < 0.05). RTI was more effective than RT in increasing the root mean square values of vastus medialis, mean spike frequency of gastrocnemius medialis, and rate of torque development of plantarflexors (P < 0.05). Stepwise regression identified the changes in mean spike frequency of gastrocnemius medialis as the best predictor of improvements in timed-up-and-go test (R-2 = 0.58, P = 0.002) and on-medication Unified Parkinson's Disease Rating Scale, motor subscale scores (R-2 = 0.40, P = 0.020). Conclusion: RTI optimizes neuromuscular adaptations, which partially explains mobility and motor sign improvements in patients with Parkinson's disease.en
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Lab Adaptat Strength Training, Sao Paulo, Brazil
dc.description.affiliationNorthwestern Univ, Dept Phys Therapy & Human Movement Sci, Chicago, IL 60611 USA
dc.description.affiliationRush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
dc.description.affiliationUniv Estadual Campinas, Dept Sport Sci, Campinas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Exercise Hemodynam Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Ctr Psychobiol & Exercise Studies, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Ctr Psychobiol & Exercise Studies, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2011/042423
dc.description.sponsorshipIDFAPESP: 2012/03056-4
dc.description.sponsorshipIDFAPESP: 2013/04970-4
dc.description.sponsorshipIDCAPES: 3095/2015-00
dc.description.sponsorshipIDCNPq: 406609/2015-2
dc.format.extent652-660
dc.identifierhttps://dx.doi.org/10.1249/MSS.0000000000001159
dc.identifier.citationMedicine And Science In Sports And Exercise. Philadelphia, v. 49, n. 4, p. 652-660, 2017.
dc.identifier.doi10.1249/MSS.0000000000001159
dc.identifier.issn0195-9131
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54873
dc.identifier.wosWOS:000397910300005
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine And Science In Sports And Exercise
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectUnstable devicesen
dc.subjectNeural activationen
dc.subjectRate of torque developmenten
dc.subjectMobilityen
dc.subjectMotor signsen
dc.subjectTotal training volumeen
dc.titleInstability Resistance Training Improves Neuromuscular Outcome in Parkinson's Diseaseen
dc.typeinfo:eu-repo/semantics/article
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