Hemodynamic, morphometric and autonomic patterns in hypertensive rats - renin-angiotensin system modulation

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dc.contributor.authorZamo, Fernanda de Souza [UNIFESP]
dc.contributor.authorLacchini, Silvia
dc.contributor.authorMostarda, Cristiano [UNIFESP]
dc.contributor.authorChiavegatto, Silvana
dc.contributor.authorMoraes-Silva, Ivana Cinthya [UNIFESP]
dc.contributor.authorOliveira, Edilamar Menezes de
dc.contributor.authorIrigoyen, Maria Claudia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:41:31Z
dc.date.available2015-06-14T13:41:31Z
dc.date.issued2010-01-01
dc.description.abstractBACKGROUND: Spontaneously hypertensive rats develop left ventricular hypertrophy, increased blood pressure and blood pressure variability, which are important determinants of heart damage, like the activation of renin-angiotensin system. AIMS: To investigate the effects of the time-course of hypertension over 1) hemodynamic and autonomic patterns (blood pressure; blood pressure variability; heart rate); 2) left ventricular hypertrophy; and 3) local and systemic Renin-angiotensin system of the spontaneously hypertensive rats. METHODS: Male spontaneously hypertensive rats were randomized into two groups: young (n=13) and adult (n=12). Hemodynamic signals (blood pressure, heart rate), blood pressure variability (BPV) and spectral analysis of the autonomic components of blood pressure were analyzed. LEFT ventricular hypertrophy was measured by the ratio of LV mass to body weight (mg/g), by myocyte diameter (μm) and by relative fibrosis area (RFA, %). ACE and ACE2 activities were measured by fluorometry (UF/min), and plasma renin activity (PRA) was assessed by a radioimmunoassay (ng/mL/h). Cardiac gene expressions of Agt, Ace and Ace2 were quantified by RT-PCR (AU). RESULTS: The time-course of hypertension in spontaneously hypertensive rats increased BPV and reduced the alpha index in adult spontaneously hypertensive rats. Adult rats showed increases in left ventricular hypertrophy and in RFA. Compared to young spontaneously hypertensive rats, adult spontaneously hypertensive rats had lower cardiac ACE and ACE2 activities, and high levels of PRA. No change was observed in gene expression of Renin-angiotensin system components. CONCLUSIONS: The observed autonomic dysfunction and modulation of Renin-angiotensin system activity are contributing factors to end-organ damage in hypertension and could be interacting. Our findings suggest that the management of hypertensive disease must start before blood pressure reaches the highest stable levels and the consequent established end-organ damage is reached.en
dc.description.affiliationFederal University of São Paulo Nephrology Department
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Heart Institute (InCor)
dc.description.affiliationUniversidade de São Paulo Institute of Biomedical Sciences Department of Anatomy
dc.description.affiliationUniversidade de São Paulo Institute of Biomedical Sciences Department of Pharmacology
dc.description.affiliationUnifespUNIFESP, Nephrology Department
dc.description.sourceSciELO
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 01/01129-0
dc.description.sponsorshipIDFAPESP: 01/00009-0
dc.format.extent85-92
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322010000100013
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 65, n. 1, p. 85-92, 2010.
dc.identifier.doi10.1590/S1807-59322010000100013
dc.identifier.fileS1807-59322010000100013.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322010000100013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5578
dc.identifier.wosWOS:000274628800012
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsAcesso aberto
dc.subjectSHRen
dc.subjectHypertensionen
dc.subjectBlood pressure variabilityen
dc.subjectRASen
dc.subjectLVHen
dc.titleHemodynamic, morphometric and autonomic patterns in hypertensive rats - renin-angiotensin system modulationen
dc.typeArtigo
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