Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism

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dc.citation.issue2
dc.citation.volume18
dc.contributor.authorAlmeida, Sandro Soares [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorAmorim, Carlos Eduardo Neves [UNIFESP]
dc.contributor.authorGregnani, Marcos Fernandes [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAraujo, Ronaldo de Carvalho [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:02:25Z
dc.date.available2020-07-17T14:02:25Z
dc.date.issued2017
dc.description.abstractIntroduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biophys, 669 Pedro de Toledo St,9th, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biophys, 669 Pedro de Toledo St,9th, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAFIP
dc.description.sponsorshipUNIFESP-EPM
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDCAPES: AUX-PE-PNPD 256/2011
dc.description.sponsorshipIDFAPESP: 2015/20082-7
dc.description.sponsorshipIDFAPESP: 2013/041364
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.description.sponsorshipIDCNPq: 141533/2012-9
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1177/1470320317703451
dc.identifier.citationJournal Of The Renin-Angiotensin-Aldosterone System. London, v. 18, n. 2, p. -, 2017.
dc.identifier.doi10.1177/1470320317703451
dc.identifier.issn1470-3203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54795
dc.identifier.wosWOS:000401524800001
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal Of The Renin-Angiotensin-Aldosterone System
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInterdisciplinary therapyen
dc.subjectMetabolic syndromeen
dc.subjectObesityen
dc.subjectAngiotensin-converting enzymeen
dc.subjectPolymorphismen
dc.titleDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphismen
dc.typeinfo:eu-repo/semantics/article
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