Cow's milk protein intolerance and chronic constipation in children

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dc.contributor.authorDaher, S.
dc.contributor.authorTahan, S.
dc.contributor.authorSole, D.
dc.contributor.authorNaspitz, C. K.
dc.contributor.authorPatricio, FRD
dc.contributor.authorNeto, U. F.
dc.contributor.authorDe Morais, M. B.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:08Z
dc.date.available2016-01-24T12:33:08Z
dc.date.issued2001-12-01
dc.description.abstractCow's milk protein (CMP) allergy was investigated in 25 children (age-range 3 months to 11 years) with chronic constipation. A diagnosis of constipation was made on the basis of a history of painful elimination of hard stools for at least 1 month, whether or not associated with a reduced frequency of stools or soiling. the children were evaluated using clinical parameters and the following laboratory tests: total serum immunoglobulin E (IgE); specific IgE (radioallergosorbent test [RAST]) for whole cow's milk, alpha-lactoalbumin, beta-lactoglobulin, and a food group; and skin-prick tests with whole milk, alpha-lactoalbumin, beta-lactoglobulin, and casein. Following the evaluation, the children were submitted to a CMP-free diet for a period of 4 weeks. in seven patients (28%)), constipation disappeared during the CMP-free diet and reappeared within 48-72 h following challenge with cow's milk. in two infants a rectal biopsy revealed allergic colitis and they therefore did not undergo the challenge. High serum levels of total IgE were observed in five. of the children who showed a clinical improvement (71%), a positive skin-test in two (29%), and detectable specific IgE in two (29%). These results suggest that CMP allergy or intolerance should be considered as a cause of chronic refractory constipation in children, although the underlying mechanism still require further investigation.en
dc.description.affiliationUNIFESP EPM, Dept Pediat, Div Rheumatol Allergy & Clin Immunol, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Pediat, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Pediat, Div Rheumatol Allergy & Clin Immunol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Pediat, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent339-342
dc.identifierhttp://dx.doi.org/10.1034/j.1399-3038.2001.0o057.x
dc.identifier.citationPediatric Allergy and Immunology. Copenhagen: Blackwell Munksgaard, v. 12, n. 6, p. 339-342, 2001.
dc.identifier.doi10.1034/j.1399-3038.2001.0o057.x
dc.identifier.issn0905-6157
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26673
dc.identifier.wosWOS:000173493600007
dc.language.isoeng
dc.publisherBlackwell Munksgaard
dc.relation.ispartofPediatric Allergy and Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectcow's milk protein intoleranceen
dc.subjectchronic constipationen
dc.subjectcow's milk allergyen
dc.titleCow's milk protein intolerance and chronic constipation in childrenen
dc.typeinfo:eu-repo/semantics/article
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