Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

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dc.contributor.authorBeres, Stephen B.
dc.contributor.authorSesso, Ricardo [UNIFESP]
dc.contributor.authorPinto, Sergio Wyton L.
dc.contributor.authorHoe, Nancy P.
dc.contributor.authorPorcella, Stephen F.
dc.contributor.authorDeleo, Frank R.
dc.contributor.authorMusser, James M.
dc.contributor.institutionMethodist Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Sao Joao Deus
dc.contributor.institutionNIH
dc.date.accessioned2016-01-24T13:51:38Z
dc.date.available2016-01-24T13:51:38Z
dc.date.issued2008-08-21
dc.description.abstractOutbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. the genome is a circular chromosome of 2,024,171 bp. the genome shares extensive gene content, including many virulence factors, with genetically related group A streptococci, but unexpectedly lacks prophages. the genome contains many apparently foreign genes interspersed around the chromosome, consistent with the presence of a full array of genes required for natural competence. An inordinately large family of genes encodes secreted extracellular collagen-like proteins with multiple integrin-binding motifs. the absence of a gene related to speB rules out the long-held belief that streptococcal pyrogenic exotoxin B or antibodies reacting with it singularly cause PSGN. Many proteins previously implicated in GAS PSGN, such as streptokinase, are either highly divergent in strain MGCS10565 or are not more closely related between these species than to orthologs present in other streptococci that do not commonly cause PSGN. Our analysis provides a comparative genomics framework for renewed appraisal of molecular events underlying APSGN pathogenesis.en
dc.description.affiliationMethodist Hosp, Ctr Mol & Translat Human Infect Dis Res, Res Inst, Houston, TX 77030 USA
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationHosp Sao Joao Deus, Div Nephrol, Divinopolis, Brazil
dc.description.affiliationNIH, Off Res Serv, Div Occupat Hlth & Safety, Hamilton, MT USA
dc.description.affiliationNIH, NIAID, Rocky Mt Lab, Lab Human Bacterial Pathogenesis, Hamilton, MT USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases
dc.description.sponsorshipIDNational Institute of Allergy and Infectious Diseases: UO1-60595
dc.format.extent16
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0003026
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 3, n. 8, 16 p., 2008.
dc.identifier.doi10.1371/journal.pone.0003026
dc.identifier.fileWOS000264426800005.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30855
dc.identifier.wosWOS:000264426800005
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGenome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Diseaseen
dc.typeinfo:eu-repo/semantics/article
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