Exercise training improves hypertension-induced autonomic dysfunction without influencing properties of peripheral cardiac vagus nerve

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dc.citation.volume208
dc.contributor.authorNeto, Octavio Barbosa
dc.contributor.authorde Sordi, Carla Cristina
dc.contributor.authorda Mota, Gustavo Ribeiro
dc.contributor.authorMarocolo, Moacir
dc.contributor.authorChriguer, Rosangela Soares [UNIFESP]
dc.contributor.authorDias da Silva, Valdo Jose
dc.coverageAmsterdam
dc.date.accessioned2020-09-01T13:20:59Z
dc.date.available2020-09-01T13:20:59Z
dc.date.issued2017
dc.description.abstractWe examined the vagal transfer function of autonomic heart rate (HR) control in anesthetized sedentary and exercise-trained Spontaneously Hypertensive Rats (SHR). To this end, male SHR and Wystar-Kyoto (WKY) rats with 48-50 weeks of age-old were divided into 4 groups: sedentary (SHRS, n = 12) and trained (SHRT, n = 14) hypertensive rats, sedentary (WKYS, n = 13) and trained (WKYT, n = 13) normotensive rats. The trained groups were submitted to swimming protocol for 9 weeks. Blood pressure (BP), HR, HR variability (HRV), BP variability (BPV), baroreflex sensitivity and cardiac tonus were recorded in baseline conditions. Following, electric stimulation of peripheral vagus nerve was performed in anesthetized conditions. Resting bradycardia was observed in SHRT and WKYT when compared to their respective sedentary groups (p < 0.001). The BP was lower in SHRT than in SHRS (p < 0.001). The SHRT and WKYT rats showed higher baroreflex-mediated tachycardia values when compared to their respective sedentary counterparts (p < 0.001). Baroreflex bradycardic response in SHRT was higher than in SHRS (p < 0.005). The SHRT and WKYT rats showed a decreased sympathetic activity in comparison to their respective sedentary groups (p < 0.05). The cardiac vagal tonus was higher in SHRT than in SHRS (p < 0.05). Regarding the dynamic transducer properties of peripheral vagus nerve to the heart no difference was observed among the groups. In conclusion, our results demonstrate that exercise training decreased BP in SHR and improved cardiovascular autonomic balance to the heart without changes in transduction properties of peripheral cardiac vagus nerve.en
dc.description.affiliationUniv Fed Triangulo Mineiro, Dept Sport Sci, Human Performance & Sport Res Grp, Av Tutunas 490, BR-38061500 Uberaba, MG, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Dept Endocrinol & Metab, Postgrad Course Hlth Sci, Uberaba, Brazil
dc.description.affiliationUniv Fed Juiz de Fora, Dept Physiol, Juiz De Fora, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Biol & Nat Sci, Dept Physiol, Uberaba, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFederal University of Triangulo Mineiro
dc.format.extent66-72
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2017.09.012
dc.identifier.citationAutonomic Neuroscience-Basic & Clinical. Amsterdam, v. 208, p. 66-72, 2017.
dc.identifier.doi10.1016/j.autneu.2017.09.012
dc.identifier.issn1566-0702
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58048
dc.identifier.wosWOS:000423642600008
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofAutonomic Neuroscience-Basic & Clinical
dc.rightsAcesso restrito
dc.subjectAutonomic dysfunctionen
dc.subjectExercise trainingen
dc.subjectVagal efferent nerveen
dc.subjectHypertensionen
dc.subjectCardiac autonomic controlen
dc.titleExercise training improves hypertension-induced autonomic dysfunction without influencing properties of peripheral cardiac vagus nerveen
dc.typeArtigo
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