Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection

Página do item simplificado
dc.citation.issue4
dc.citation.volume18
dc.contributor.authorTorrecilhas, Ana Claudia [UNIFESP]
dc.contributor.authorXander, Patricia [UNIFESP]
dc.contributor.authorFerreira, Karen Spadari [UNIFESP]
dc.contributor.authorBatista, Wagner Luiz [UNIFESP]
dc.coverageSharjah
dc.date.accessioned2020-07-08T13:09:54Z
dc.date.available2020-07-08T13:09:54Z
dc.date.issued2018
dc.description.abstractThe neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of alternative methods for testing new compounds against these diseases. For the implementation of alternative methods, it is necessary to apply the principles of replacement, reduction and refinement (the 3Rs) for the use of laboratory animals. Accordingly, the present review addressed a variety of alternative models to study the infections caused by protozoa and fungi. Overall, vertebrate and invertebrate models of fungal infection have been used to elucidate host-pathogen interactions. However, until now the insect model has not been used in protozoal studies as an alternative method, but there is interest in the scientific community to try new tools to screen alternative drugs to control and prevent protozoal infections.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Farmaceut, Lab Imunol Celular & Bioquim Fungos & Protozoario, Campus Diadema,Rua Sao Nicolau 210,4 Andar, BR-04023900 Diadema, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Farmaceut, Lab Imunol Celular & Bioquim Fungos & Protozoario, Campus Diadema,Rua Sao Nicolau 210,4 Andar, BR-04023900 Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 2014/13961-1pt
dc.format.extent300-311
dc.identifierhttps://dx.doi.org/10.2174/1568026618666180412154519
dc.identifier.citationCurrent Topics In Medicinal Chemistry. Sharjah, v. 18, n. 4, p. 300-311, 2018.
dc.identifier.doi10.2174/1568026618666180412154519
dc.identifier.issn1568-0266
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54283
dc.identifier.wosWOS:000433386800006
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Topics In Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFungalen
dc.subjectLeishmaniasisen
dc.subjectChagas diseaseen
dc.subjectAlternative methodsen
dc.subjectAlternative host modelsen
dc.subjectTarget-based approachen
dc.titleAlternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infectionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
ICAQF - Artigos