Acromegaly and pregnancy: a contemporary review

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dc.citation.issue1]
dc.citation.volume177]
dc.contributor.authorAbucham, Julio [UNIFESP]
dc.contributor.authorBronstein, Marcello D.
dc.contributor.authorDias, Monike L.
dc.coverageBristol
dc.date.accessioned2020-06-26T16:30:33Z
dc.date.available2020-06-26T16:30:33Z
dc.date.issued2017
dc.description.abstractAlthough fertility is frequently impaired in women with acromegaly, pregnancy is apparently becoming more common due to improvement in acromegaly treatment as well as in fertility therapy. As a result, several studies on pregnancy in patients with acromegaly have been published in recent years adding new and relevant information to the preexisting literature. Also, new GH assays with selective specificities and the knowledge of the expression of the various GH genes have allowed a better understanding of somatotrophic axis function during pregnancy. In this review, we show that pregnancy in women with acromegaly is generally safe, usually with tumoral and hormonal stability. Although the paucity of data limits evidence-based recommendations for preconception counseling and pregnancy surveillance, controlling tumor size and hormonal activity before pregnancy is highly recommended to ensure better outcomes, and surgical control should be attempted when feasible. Treatment interruption at pregnancy confirmation has also proven to be safe, as drugs are not formally allowed to be used during pregnancy. Drug exposure (somatostatin analogs) during early or whole pregnancy might increase the chance of a lower birth weight. Aggressive disease is uncommon and may urge individual decisions such as surgery or drug treatment during pregnancy or lactation.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Neuroendocrinol Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Div Endocrinol & Metab, Neuroendocrinol Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Endocrinol Unit, Goiania, Go, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Neuroendocrinol Unit, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentR1-R12
dc.identifierhttp://dx.doi.org/10.1530/EJE-16-1059]
dc.identifier.citationEuropean Journal Of Endocrinology. Bristol, v. 177, n. 1, p. R1-R12, 2017.
dc.identifier.doi10.1530/EJE-16-1059
dc.identifier.issn0804-4643
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53624
dc.identifier.wosWOS:000403055700002
dc.language.isoeng
dc.publisherBioscientifica Ltd
dc.relation.ispartofEuropean Journal Of Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleAcromegaly and pregnancy: a contemporary reviewen
dc.typeinfo:eu-repo/semantics/article
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