Long-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patients

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dc.citation.issue12
dc.citation.volume40
dc.contributor.authorGodoy, Luciana B. M. [UNIFESP]
dc.contributor.authorPalombini, Luciana [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.authorDal-Fabbro, Cibele [UNIFESP]
dc.contributor.authorGuimaraes, Thais Moura [UNIFESP]
dc.contributor.authorKlichouvicz, Priscila Calixto [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorTogeiro, Sonia Maria [UNIFESP]
dc.coverageCary
dc.date.accessioned2020-09-01T13:21:03Z
dc.date.available2020-09-01T13:21:03Z
dc.date.issued2017
dc.description.abstractObjectives: To evaluate the long-term effects of an oral appliance on clinical symptoms, respiratory sleep parameters, sleep quality, and sustained attention in patients with upper airway resistance syndrome (UARS) were compared with placebo. Methods: This study was a randomized placebo-controlled clinical trial. Thirty UARS patients were randomized in two groups: placebo and mandibular advancement device (MAD) groups. UARS criteria were presence of sleepiness (Epworth Sleepiness Scale >= 10) and/or fatigue (Modified Fatigue Impact Scale >= 38) associated with an apnea/hypopnea index <= 5 and a respiratory disturbance index (RDI) > 5 events/hour of sleep, and/or flow limitation in more than 30% of total sleep time. All patients completed the Pittsburgh Sleep Quality Index (PSQI), the Functional Outcomes of Sleep Questionnaire, the Beck Anxiety and Depression Inventories, underwent full-night polysomnography, multiple sleep latency test, and Psychomotor Vigilance Test (PVT). Evaluations were performed before and after 1.5 years of treatment. Results: RDI, number of respiratory effort-related arousal, percentage of total sleep time with flow limitation, and arousal index significantly decreased after 1.5 years of MAD treatment. PSQI total score improved, severity of depression symptoms decreased, and mean reaction time in the PVT, based on the first measurement taken at 8: 00 am, significantly decreased (p=.03) at the end of the protocol. Conclusions: The MAD was effective in decreasing respiratory events in UARS patients. For UARS, 1.5 years of oral appliance therapy also improved sleep quality and sustained attention, and decreased the severity of depression symptoms.en
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Med & Biol Sono, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Med & Biol Sono, Dept Psicobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCAPES
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1093/sleep/zsx175
dc.identifier.citationSleep. Cary, v. 40, n. 12, p. -, 2017.
dc.identifier.doi10.1093/sleep/zsx175
dc.identifier.issn1550-9109
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58068
dc.identifier.wosWOS:000419000600014
dc.language.isoeng
dc.publisherOxford Univ Press Inc
dc.relation.ispartofSleep
dc.rightsAcesso aberto
dc.subjectUpper airway resistance syndromeen
dc.subjectfatigueen
dc.subjectexcessive daytime sleepinessen
dc.subjectmandibular advancement deviceen
dc.subjectsleep disordered breathingen
dc.subjectoral appliance therapyen
dc.titleLong-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patientsen
dc.typeArtigo
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