Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys

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dc.contributor.authorBanks, Matthew L.
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorMurnane, Kevin S.
dc.contributor.authorMeyer, Rebecca C.
dc.contributor.authorHowell, Leonard L.
dc.contributor.institutionEmory Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:34Z
dc.date.available2016-01-24T13:58:34Z
dc.date.issued2009-08-01
dc.description.abstractDiphenhydramine (DPH) is an over-the-counter medication used in the treatment of allergic symptoms. While DPH abuse is infrequent, recent preclinical evidence suggests that DPH and cocaine combinations may have enhanced reinforcing properties.The aims were to assess the reinforcing effectiveness of cocaine and DPH alone or in combination under a second-order schedule of reinforcement and to examine the neurochemical basis of this interaction using in vivo microdialysis in awake rhesus monkeys.Cocaine (0.03-0.3 mg/kg per injection), DPH (0.3-3.0 mg/kg per injection), or a combination was available under a second-order schedule of intravenous drug reinforcement (n = 3). in microdialysis studies, noncontingent cocaine (0.1-1.0 mg/kg, iv), DPH (1.7 and 3.0 mg/kg, iv), or a combination was administered and changes in extracellular dopamine levels in the caudate nucleus were examined (n = 3-5).Cocaine and DPH dose-dependently maintained operant responding. Dose combinations of 1.0 or 1.7 mg/kg per injection DPH and 0.03 mg/kg per injection cocaine maintained greater rates of operant responding than 0.03 mg/kg per injection cocaine alone in the second component of the behavioral session. in microdialysis studies, cocaine dose-dependently increased extracellular dopamine levels, but no dose of DPH tested significantly increased dopamine levels above baseline. Moreover, combining DPH with cocaine did not enhance cocaine-induced dopamine increases.The results support previous evidence of enhanced reinforcement with cocaine and DPH combinations and extend this finding to operant behavior maintained under a second-order schedule. However, the reinforcing effects of DPH alone or in combination with cocaine do not appear to be mediated via changes in dopamine overflow.en
dc.description.affiliationEmory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationEmory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNIH
dc.description.sponsorshipIDNIH: DA00517
dc.description.sponsorshipIDNIH: DA10344
dc.description.sponsorshipIDNIH: DA15040
dc.description.sponsorshipIDNIH: RR00165
dc.format.extent467-474
dc.identifierhttp://dx.doi.org/10.1007/s00213-009-1555-y
dc.identifier.citationPsychopharmacology. New York: Springer, v. 205, n. 3, p. 467-474, 2009.
dc.identifier.doi10.1007/s00213-009-1555-y
dc.identifier.issn0033-3158
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31702
dc.identifier.wosWOS:000268120400011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPsychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectAntihistamineen
dc.subjectCocaineen
dc.subjectMonkeyen
dc.subjectMicrodialysisen
dc.subjectDopamineen
dc.subjectSelf-administrationen
dc.titleBehavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeysen
dc.typeinfo:eu-repo/semantics/article
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