The involvement of autoimmunity against retinal antigens in determining disease severity in toxoplasmosis

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dc.contributor.authorVallochi, A. L.
dc.contributor.authorRios, L. D.
dc.contributor.authorNakamura, M. V.
dc.contributor.authorSilveira, C.
dc.contributor.authorMuccioli, C.
dc.contributor.authorMartins, M. C.
dc.contributor.authorBelfort, R.
dc.contributor.authorRizzo, L. V.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFundacao Zerbini
dc.date.accessioned2016-01-24T12:37:39Z
dc.date.available2016-01-24T12:37:39Z
dc.date.issued2005-02-01
dc.description.abstractPurpose: Ocular lesions are frequent in various individuals infected with Toxoplasma gondii. Disease intensity in ocular toxoplasmosis varies greatly between patients. Autoimmunity has been suggested as a possible component to retinal destruction.Methods: Immunologic parameters in the response to retina antigens were evaluated in infected persons with and without ocular lesions and in non-infected controls. Subjects were divided into groups on the basis of titers of serum antibodies to T. gondii, presence and severity of ocular lesions, and clinical history.Results: Peripheral blood mononuclear cells from patients with mild disease responded to one or more retinal antigens with a significantly higher frequency than patients without disease or with severe disease. Interestingly, the cytokines produced by the proliferating mononuclear cells did not follow any specific patterns, except for the fact that IL-4 and IL-5 were seldom detected.Conclusions: Our results suggest that although the presence of an immune response towards autoantigens is not protective against the development of ocular lesions by the T. gondii, it may protect against the development of severe disease. (c) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Immunol, Inst Ciencias Biomed, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationFundacao Zerbini, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Div Clin Immunol & Allergy, LIM 60, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Immunol, Inst Ciencias Biomed, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Div Clin Immunol & Allergy, LIM 60, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent25-32
dc.identifierhttp://dx.doi.org/10.1016/j.jaut.2004.11.003
dc.identifier.citationJournal of Autoimmunity. London: Academic Press Ltd- Elsevier B.V., v. 24, n. 1, p. 25-32, 2005.
dc.identifier.doi10.1016/j.jaut.2004.11.003
dc.identifier.issn0896-8411
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28139
dc.identifier.wosWOS:000227592600003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Autoimmunity
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectautoimmunityen
dc.subjectIRBPen
dc.subjectocular toxoplasmosisen
dc.subjectretinal antigensen
dc.subjectS-Agen
dc.subjectToxoplasma gondiien
dc.titleThe involvement of autoimmunity against retinal antigens in determining disease severity in toxoplasmosisen
dc.typeinfo:eu-repo/semantics/article
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