Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study

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dc.contributor.authorAndaku, Daniela Kuguimoto [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.authorCarneiro, Glaucia [UNIFESP]
dc.contributor.authorHix, Sonia [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorTogeiro, Sonia Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Med ABC FUABC
dc.date.accessioned2016-01-24T14:39:54Z
dc.date.available2016-01-24T14:39:54Z
dc.date.issued2015-01-14
dc.description.abstractBackground: the simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients. Both conditions, if present in OSA, have been reported to be associated with inflammation and disruption of oxidative stress balance that impair the cardiovascular system. To verify the impact of daytime sleepiness on inflammatory and oxidative stress markers, we evaluated OSA patients without significant metabolic disturbance.Methods: Thirty-five male subjects without diagnostic criteria for metabolic syndrome (Adult Treatment Panel III) were distributed into a control group (n = 10) (43 +/- 10.56 years, apnea-hypopnea index - AHI 2.71 +/- 1.48/hour), a non-sleepy OSA group (n = 11) (42.36 +/- 9.48 years, AHI 29.48 +/- 22.83/hour) and a sleepy OSA group (n = 14) (45.43 +/- 10.06 years, AHI 38.20 +/- 25.54/hour). Excessive daytime sleepiness was considered when Epworth sleepiness scale score was >= 10. Levels of high-sensitivity C-reactive protein, homocysteine and cysteine, and paraoxonase-1 activity and arylesterase activity of paraoxonase-1 were evaluated.Results: Patients with OSA and excessive daytime sleepiness presented increased high-sensitivity C-reactive protein levels even after controlling for confounders. No significant differences were found among the groups in paraoxonase-1 activity nor arylesterase activity of paraoxonase-1. AHI was independently associated and excessive daytime sleepiness tended to have an association with high-sensitivity C-reactive protein.Conclusions: in the absence of metabolic syndrome, increased inflammatory response was associated with AHI and daytime sleepiness, while OSA was not associated with abnormalities in oxidative stress markers.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Med, São Paulo, Brazil
dc.description.affiliationFac Med ABC FUABC, Dept Morphol & Physiol, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.description.sponsorshipIDCNPq: 501343/2010-5
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1186/s12931-015-0166-x
dc.identifier.citationRespiratory Research. London: Biomed Central Ltd, v. 16, 6 p., 2015.
dc.identifier.doi10.1186/s12931-015-0166-x
dc.identifier.fileWOS000348551000001.pdf
dc.identifier.issn1465-993X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38635
dc.identifier.wosWOS:000348551000001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofRespiratory Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObstructive sleep apneaen
dc.subjectExcessive daytime sleepinessen
dc.subjectMetabolic syndromeen
dc.subjectInflammationen
dc.subjectC-reactive proteinen
dc.subjectOxidative stressen
dc.titleSleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional studyen
dc.typeinfo:eu-repo/semantics/article
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