Morbimortality of Pandemic Influenza A H1N1 Infection in Kidney Transplant Recipients Requiring Hospitalization: A Comparative Analysis With Nonimmunocompromised Patients

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dc.contributor.authorCamargo, Luis Fernando A. [UNIFESP]
dc.contributor.authorSandes-Freitas, Taina V. de [UNIFESP]
dc.contributor.authorSilva, Camila D. R. [UNIFESP]
dc.contributor.authorBittante, Carolina D. [UNIFESP]
dc.contributor.authorOno, Gislaine [UNIFESP]
dc.contributor.authorCorrea, Luci [UNIFESP]
dc.contributor.authorSilva, Moacyr [UNIFESP]
dc.contributor.authorBellei, Nancy Cristina J. [UNIFESP]
dc.contributor.authorGoto, Janaina M. [UNIFESP]
dc.contributor.authorMedeiros, Eduardo A. S. [UNIFESP]
dc.contributor.authorGomes, Pollyane S. [UNIFESP]
dc.contributor.authorMedina-Pestana, Jose O. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Rim & Hipertensao
dc.date.accessioned2016-01-24T14:17:48Z
dc.date.available2016-01-24T14:17:48Z
dc.date.issued2012-01-15
dc.description.abstractBackground. Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce data compare these outcomes with nonimmunocompromised patients.Methods. We retrospectively reviewed and compared the clinical presentation, morbidity, and mortality of all kidney transplant (KT) and nonimmunocompromised (non-KT) patients admitted for at least 12 hr with a diagnosis of pandemic influenza A H1N1 infection in a single hospital complex during the 2009 pandemic.Results. There were 22 patients in the KT group (29.3%) and 53 in the non-KT group (70.7%). the prevalence of diabetes was higher in KT group (27.3% vs. 5.7%) while chronic pulmonary disease was more frequent in non-KT group (34% vs. 9.1%). Clinical and radiological presentations and duration of disease were similar between the two groups. the incidence of acute renal failure was higher among KT patients (40.9% vs. 17%). No differences in the rate of intensive care unit admission (22.7% vs. 22.6%) or hospital mortality (9.1% vs. 7.5%) were observed. for the overall population, poor outcome, defined as intensive care unit admission or death, was associated with in-hospital acquisition (relative risk [RR] = 42.6 [95% confidence interval {95% CI} 2.2-831.9], P = 0.003), symptom onset more than 48 hr (RR = 12.17 [95% CI 1.3-117.2], P = 0.007), and acute renal failure (RR = 11.8 [95% CI 2.9-48.8], P = 0.001). Among KT recipients, in-hospital acquisition was the only covariate associate with poor outcome (RR = 30.0 [95% CI 2.1421.1], P = 0.004).Conclusions. No significant differences in morbidity and mortality were observed comparing KT and non-KT patients infected with pandemic H1N1 influenza A virus.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, BR-04044020 São Paulo, Brazil
dc.description.affiliationHosp Rim & Hipertensao, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent69-72
dc.identifierhttp://dx.doi.org/10.1097/TP.0b013e31823aa528
dc.identifier.citationTransplantation. Philadelphia: Lippincott Williams & Wilkins, v. 93, n. 1, p. 69-72, 2012.
dc.identifier.doi10.1097/TP.0b013e31823aa528
dc.identifier.issn0041-1337
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34530
dc.identifier.wosWOS:000298660800011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofTransplantation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectH1N1en
dc.subjectInfluenzaen
dc.subjectTransplantationen
dc.titleMorbimortality of Pandemic Influenza A H1N1 Infection in Kidney Transplant Recipients Requiring Hospitalization: A Comparative Analysis With Nonimmunocompromised Patientsen
dc.typeinfo:eu-repo/semantics/article
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