STRUCTURAL and FUNCTIONAL-PROPERTIES of TRYPANOSOMA TRANS-SIALIDASE

dc.contributor.authorSchenkman, S. [UNIFESP]
dc.contributor.authorEichinger, D.
dc.contributor.authorPereira, MEA
dc.contributor.authorNussenzweig, V
dc.contributor.institutionNYU
dc.contributor.institutionTUFTS UNIV
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:16Z
dc.date.available2016-01-24T11:40:16Z
dc.date.issued1994-01-01
dc.description.abstractSialic acids and sialidases play important roles in cellular interactions and modulate the recognition of pathogenic microbes by mammalian host cells. Protozoan parasites of the genus Trypanosoma express a unique sialic acid metabolizing enzyme. This enzyme, named trans-sialidase (TS), catalyzes the transfer of sialic acids from host glycoconjugates to acceptor molecules of the parasite plasma membrane. in African trypanosomes, the agents of sleeping sickness, TS is found only in forms developing within the insect vector, and the enzyme sialylates the major surface protein. in Trypanosoma cruzi, the causative agent of Chagas' disease in Central and South America, TS is expressed both in the insect and mammalian forms of the parasite. the T. cruzi enzyme has been biochemically characterized, and the gene encoding the enzyme has been cloned. the enzyme sialylates abundant mucin-like molecules present on the surface of the parasite. Several lines of evidence suggest that TS and sialic acid accepters on the surface of T. cruzi participate in host-parasite interactions and mediate the initial stages of the trypanosomes' invasion of host cells.en
dc.description.affiliationNYU,MED CTR,DEPT PATHOL,MICHAEL HEIDELBERGER DIV IMMUNOL,NEW YORK,NY 10016
dc.description.affiliationTUFTS UNIV,NEW ENGLAND MED CTR HOSP,DEPT MED,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Departamento de Microbiologia, Imunologia e Parasitologia, São Paulo, Brasil
dc.description.sourceWeb of Science
dc.format.extent499-523
dc.identifierhttp://dx.doi.org/10.1146/annurev.mi.48.100194.002435
dc.identifier.citationAnnual Review of Microbiology. Palo Alto: Annual Reviews Inc, v. 48, p. 499-523, 1994.
dc.identifier.doi10.1146/annurev.mi.48.100194.002435
dc.identifier.issn0066-4227
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25382
dc.identifier.wosWOS:A1994PM44600019
dc.language.isoeng
dc.publisherAnnual Reviews Inc
dc.relation.ispartofAnnual Review of Microbiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSIALIC ACIDSen
dc.subjectCELL INVASIONen
dc.subjectMUCINen
dc.subjectSIALIDASEen
dc.subjectOLIGOSACCHARIDE SYNTHESISen
dc.titleSTRUCTURAL and FUNCTIONAL-PROPERTIES of TRYPANOSOMA TRANS-SIALIDASEen
dc.typeinfo:eu-repo/semantics/article
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