Bloodstream infections in late-stage acquired immunodeficiency syndrome patients evaluated by a lysis centrifugation system

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dc.contributor.authorRosas, Rc
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorMatta, Daniel Archimedes da [UNIFESP]
dc.contributor.authorLopes, Hv
dc.contributor.authorPignatari, Antonio Carlos Campos [UNIFESP]
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHospital e Maternidade Santa Marcelina
dc.contributor.institutionHospital Heliópolis
dc.date.accessioned2015-06-14T13:30:03Z
dc.date.available2015-06-14T13:30:03Z
dc.date.issued2003-06-01
dc.description.abstractOpportunistic infections, which affect acquired immunodeficiency syndrome (Aids) patients, are frequently disseminated and may cause bloodstream infections (BSI). The aim of this study was to evaluate the main causes of BSI in Aids patients with advanced stage of the disease, with special emphasis on the identification of fungemia. During a 21 months period, all patients with Aids (CD4 < 200) and febrile syndrome admitted to 3 university hospitals were systematically evaluated. For each patient presenting fever, a pair of blood cultures was collected and processed by using a commercial lysis-centrifugation system. One hundred and eleven patients (75 males) with a mean age of 36 years (median 33 years) and mean CD4 count of 64 cells/ml were included. Among the 111 patients evaluated we documented 54 episodes of BSI, including 46 patients with truly systemic infections and 8 episodes considered as contaminants. BSI were caused by gram-positive bacteria (43%), fungi (20%), gram-negative bacteria (15%), mycobacteria (15%), and mixed flora (7%). The crude mortality rate of our patients was 39%, being 50% for patients with BSI and 31% for the others. In conclusion, BSI are a common related to systemic infections on Aids patients with advanced stage of disease and is associated with a high rate of mortality.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Hospital São Paulo
dc.description.affiliationHospital e Maternidade Santa Marcelina
dc.description.affiliationHospital Heliópolis
dc.description.affiliationUnifespUNIFESP, Hospital São Paulo
dc.description.sourceSciELO
dc.format.extent529-532
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762003000400019
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 98, n. 4, p. 529-532, 2003.
dc.identifier.doi10.1590/S0074-02762003000400019
dc.identifier.fileS0074-02762003000400019.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02762003000400019
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1760
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectacquired immunodeficiency syndrome (Aids)en
dc.subjectbloodstream infectionen
dc.subjectlysis centrifugationen
dc.titleBloodstream infections in late-stage acquired immunodeficiency syndrome patients evaluated by a lysis centrifugation systemen
dc.typeinfo:eu-repo/semantics/article
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