Expression of nestin in the hippocampal submitted to the pilocarpine model formation of rats of epilepsy

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dc.contributor.authorScorza, C. A.
dc.contributor.authorArida, R. M.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.authorNaffah-Mazzacoratti, M. G.
dc.contributor.authorScorza, F. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Mogi Cruzes
dc.date.accessioned2016-01-24T12:37:43Z
dc.date.available2016-01-24T12:37:43Z
dc.date.issued2005-03-01
dc.description.abstractNestin is an embryonic intermediate filament component protein, transiently expressed by the immediate precursor cells of neurons and glia, during brain development. We studied the nestin distribution in the hippocampal formation of rats submitted to pilocarpine model of epilepsy. Animals were studied during the acute, silent and chronic phases. Rats from control and acute groups presented absence of nestin-immunoreactivity (IR) in the hippocampal cells. in contrast, cells from this region presented strong nestin IR during the silent phase (3 and 7 days after status epilepticus (SE) onset), disappearing 14 days after SE. Nestin IR cells were scattered expressed in all hippocampal formation during the chronic phase. Almost all nestin IR cells exhibited glial fibrillary acidic protein (GFAP), which seems to revert to a more primitive glial form, as part of an adaptive response, transiently re-expressing phenotypic features typical of earlier stages of glial development. the re-expression of this developmental protein in the damaged cerebral tissue suggests that nestin may play an important role in the reconstruction of the glial cytoskeleton and/or remodeling events occurring in the pilocarpine model of epilepsy. Understanding how astrocytes influence network function in the injured hippocampus may, therefore, provide insight into epileptogenic mechanisms. (C) 2004 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.en
dc.description.affiliationUNIFESP, Lab Neurol Expt, BR-04042003 São Paulo, Brazil
dc.description.affiliationUniv Mogi Cruzes, NPT UMC, Lab Neurociencias Nucl Pesquisas Tecnol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Lab Neurol Expt, BR-04042003 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent285-291
dc.identifierhttp://dx.doi.org/10.1016/j.neures.2004.12.002
dc.identifier.citationNeuroscience Research. Clare: Elsevier Sci Ireland Ltd, v. 51, n. 3, p. 285-291, 2005.
dc.identifier.doi10.1016/j.neures.2004.12.002
dc.identifier.issn0168-0102
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28184
dc.identifier.wosWOS:000227444800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectnestinen
dc.subjectepilepsyen
dc.subjecthippocampusen
dc.subjectastrocytesen
dc.subjectpilocarpineen
dc.titleExpression of nestin in the hippocampal submitted to the pilocarpine model formation of rats of epilepsyen
dc.typeinfo:eu-repo/semantics/article
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