Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema

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dc.citation.issue10
dc.citation.volume21
dc.contributor.authorGames, Ellen [UNIFESP]
dc.contributor.authorGuerreiro, Marina [UNIFESP]
dc.contributor.authorSantana, Fernanda Paula Roncon [UNIFESP]
dc.contributor.authorPinheiro, Nathalia Montouro
dc.contributor.authorOliveira, Emerson Alves de [UNIFESP]
dc.contributor.authorLopes, Fernanda Degobbi Tenorio Quirino dos Santos
dc.contributor.authorOlivo, Clarice Rosa
dc.contributor.authorTibério, Iolanda de Fátima Lopes Calvo
dc.contributor.authorMartins, Milton de Arruda
dc.contributor.authorLago, Joao Henrique Ghilardi [UNIFESP]
dc.contributor.authorPrado, Carla Máximo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageBasel
dc.date.accessioned2020-07-31T12:47:38Z
dc.date.available2020-07-31T12:47:38Z
dc.date.issued2016
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham. (Verbenaceae). Methods: Mices received porcine pancreatic elastase (PPE) and were treated with p-cymene, carvacrol, thymol or vehicle 30 min later and again on 7th, 14th and 28th days. Lung inflammatory profile and histological sections were evaluated. Results: In the elastase-instilled animals, the tested monoterpenes reduced alveolar enlargement, macrophages and the levels of IL-1 beta, IL-6, IL-8 and IL-17 in bronchoalveolar lavage fluid (BALF), and collagen fibers, MMP-9 and p-65-NF-kappa B-positive cells in lung parenchyma (p < 0.05). All treatments attenuated levels of 8-iso-PGF2 alpha but only thymol was able to reduced exhaled nitric oxide (p < 0.05). Conclusion: Monoterpenes p-cymene, carvacrol and thymol reduced lung emphysema and inflammation in mice. No significant differences among the three monoterpenes treatments were found, suggesting that the presence of hydroxyl group in the molecular structure of thymol and carvacrol do not play a central role in the anti-inflammatory effects.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, BR-09913030 Diadema, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Med, BR-01246903 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Exact Sci & Earth, BR-09913030 Diadema, Brazil
dc.description.affiliationFed Univ ABC, Ctr Nat Sci & Humanities, BR-09606045 Santo Andre, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUnifespDepartment of Biological Science, Universidade Federal de São Paulo, Diadema 09913-030, Brazil
dc.description.affiliationUnifespDepartment of Exact Science and Earth, Universidade Federal de São Paulo, Diadema 09913-030, Brazil
dc.description.affiliationUnifespDepartment of Bioscience, Federal University of São Paulo, Campus Baixada Santista, Santos 11015-020, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipLaboratorio de Investigacao Medica, Hospital das Clinicas, Faculdade de Medicina, University of Sao Paulo (LIM)
dc.description.sponsorshipIDCNPq: 300546/2012-2
dc.description.sponsorshipIDCNPq: 304465/2012-7
dc.description.sponsorshipIDCNPq: 476877/2012-1
dc.description.sponsorshipIDCNPq: 306278/2015-4
dc.description.sponsorshipIDFAPESP: 2011/51739-0
dc.description.sponsorshipIDFAPESP: 2013/02881-4
dc.description.sponsorshipIDFAPESP: 2008/55359-5
dc.description.sponsorshipIDFAPESP: 2015/11936-2
dc.description.sponsorshipIDFAPESP: 2014/25689-4
dc.description.sponsorshipIDLIM: LIM20
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.3390/molecules21101390
dc.identifier.citationMolecules. Basel, v. 21, n. 10, p. -, 2016.
dc.identifier.doi10.3390/molecules21101390
dc.identifier.fileWOS000389917900127.pdf
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56953
dc.identifier.wosWOS:000389917900127
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOPDen
dc.subjectElastase-induced emphysemaen
dc.subjectMonoterpenesen
dc.subjectP-cymeneen
dc.subjectCarvacrolen
dc.subjectThymolen
dc.subjectLung inflammationen
dc.titleStructurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysemaen
dc.typeinfo:eu-repo/semantics/article
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