Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique

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dc.citation.volume119
dc.contributor.authorLanza, Fernanda Cordoba [UNIFESP]
dc.contributor.authorWandalsen, Gustavo Falbo [UNIFESP]
dc.contributor.authorDos Santos, Amelia Miyashiro [UNIFESP]
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractBackground: Bronchodilator response (BDR) analyzed by the raised volume rapid thoracic compression (RVRTC) in wheezing infants is not yet well described, although bronchodilators (BD) are routine in the treatment of this population. Objective: To evaluate BDR by RVRTC technique in infants with recurrent wheezing and compare to control group. Method: Cross sectional study, 45 infants, age 56 weeks (38-67 weeks). Two groups: wheezing group (WG: history of recurrent wheezing) and control group (CG). RVRTC was evaluated, FVC, FEV0.5, FEF50, FEF75, FEF85, FEF25-75 were measured. Salbutamol was delivered to infants and RVRTC evaluated again. BDR was determined by the increase greater than two standard deviation from the mean change in the CG. Results: In WG (n = 32) lung function was worse than in CG (n = 13): FEV0.5: 0.0(-0.9-0.9z score) vs 0.8(0.2-1.4z score)en
dc.description.abstractFEF50: 0.2(-0.3-1.1z score) vs 0.9(0.5-1.4z score)en
dc.description.abstractand FEF25-75: 0.2(-0.5-1.1z score) vs 1.1(0.6-1.6z score), respectively, p < 0.05. Both groups had similar increase after BD. In WG 11 patients (34%) were responder and these had worse lung function compared to nonresponder (n = 21) (p < 0.05). The increase in lung function after BD in responder was higher than in nonresponder: FEV0.5: 6.5(2.1-7.1%) vs -0.5(-2.5-0.7%), FEF50: 5.1(2.7-11.7%) vs 0.4(-1.1-2.8%), FEF75: 20.7(4.7-23.6%) vs -1.3(-6.4-3.9%), FEF25-75: 9.9(3.8-16.4%) vs 0.0(-1.5-1.0%), respectively, p < 0.05. Conclusion: 34% WG showed BDR measured by the RVRTC. The best variables to detect BDR were FEF75, FEF25-75 and FEV0.5. Patients with worse lung function showed better response to BD. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Pediat, Discipline Allergy Clin Immunol & Rheumatol, Otonis St 725, BR-04025002 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Pediat, Neonatal Div Med, Marselhesa St 630, BR-04020060 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDiscipline of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Otonis St 725, 04025-002, Brazil
dc.description.affiliationUnifespNeonatal Division of Medicine – Department of Pediatrics – Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Marselhesa St 630, 04020-060, Brazil
dc.description.sourceWeb of Science
dc.format.extent29-34
dc.identifierhttp://dx.doi.org/10.1016/j.rmed.2016.08.013
dc.identifier.citationRespiratory Medicine. London, v. 119, p. 29-34, 2016.
dc.identifier.doi10.1016/j.rmed.2016.08.013
dc.identifier.issn0954-6111
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57000
dc.identifier.wosWOS:000385321200006
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofRespiratory Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLung functionen
dc.subjectWheezingen
dc.subjectInfantsen
dc.subjectBronchodilatoren
dc.titleBronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression techniqueen
dc.typeinfo:eu-repo/semantics/article
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