Relationship between seizure frequency and number of neuronal and non-neuronal cells in the hippocampus throughout the life of rats with epilepsy

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dc.citation.volume1634
dc.contributor.authorLopim, Glauber Menezes [UNIFESP]
dc.contributor.authorCampos, Diego Vannucci [UNIFESP]
dc.contributor.authorda Silva, Sergio Gomes
dc.contributor.authorde Almeida, Alexandre Aparecido [UNIFESP]
dc.contributor.authorLent, Roberto
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-08-21T17:00:07Z
dc.date.available2020-08-21T17:00:07Z
dc.date.issued2016
dc.description.abstractThe relationship between seizure frequency and cell death has been a subject of controversy. To tackle this issue, we determined the frequency of seizures and the total number of hippocampal cells throughout the life of rats with epilepsy using the pilocarpine model. Seizure frequency varied in animals with epilepsy according to which period of life they were in, with a progressive increase in the number of seizures until 180 days (sixth months) of epileptic life followed by a decrease (330 days-eleventh month) and subsequently stabilization of seizures. Cell counts by means of isotropic fractionation showed a reduction in the number of hippocampal neuronal cells following 30, 90, 180 and 360 days of spontaneous recurrent seizures (SRS) in rats compared to their controls (about 25%-30% of neuronal cell reduction). In addition, animals with 360 days of SRS showed a reduction in the number of neuronal cells when compared with animals with 90 and 180 days of seizures. The total number of hippocampal non-neuronal cells was reduced in rats with epilepsy after 30 days of SRS, but no significant alteration was observed on the 90th, 180th and 360th days. The total number of neuronal cells was negatively correlated with seizure frequency, indicating an association between occurrence of epileptic seizures throughout life and neuronal loss. In sum, our results add novel data to the literature concerning the time-course of SRS and hippocampal cell number throughout epileptic life. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Ed Ciencias Biomed, Rua Botucatu 862,5 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Cerebro INCE, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Ciencias Biomed, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Ed Ciencias Biomed, Rua Botucatu 862,5 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT)
dc.format.extent179-186
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2015.12.055
dc.identifier.citationBrain Research. Amsterdam, v. 1634, p. 179-186, 2016.
dc.identifier.doi10.1016/j.brainres.2015.12.055
dc.identifier.fileWOS000372688300018.pdf
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57873
dc.identifier.wosWOS:000372688300018
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsyen
dc.subjectSeizure frequencyen
dc.subjectHippocampusen
dc.subjectNeuronal cellen
dc.subjectNon-neuronal cellen
dc.titleRelationship between seizure frequency and number of neuronal and non-neuronal cells in the hippocampus throughout the life of rats with epilepsyen
dc.typeinfo:eu-repo/semantics/article
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