Association of Sarcopenia With Nutritional Parameters, Quality of Life, Hospitalization, and Mortality Rates of Elderly Patients on Hemodialysis

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dc.citation.issue3
dc.citation.volumev. 28
dc.contributor.authorGiglio, Juliana
dc.contributor.authorKamimura, Maria Ayako [UNIFESP]
dc.contributor.authorLamarca, Fernando
dc.contributor.authorRodrigues, Juliana
dc.contributor.authorSantin, Fernanda
dc.contributor.authorAvesani, Carla Maria [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-20T16:30:55Z
dc.date.available2020-07-20T16:30:55Z
dc.date.issued2018
dc.description.abstractObjective: This study aimed to assess whether diminished muscle mass, diminished muscle strength, or both conditions (sarcopenia) are associated with worse nutritional status, poor quality of life (QoL), and hard outcomes, such as hospitalization and mortality, in elderly patients on maintenance hemodialysis (MHD). Design and Subjects: This is a multicenter observational longitudinal study that included 170 patients on MHD (age 70 6 7 years, 65% male) from 6 dialysis centers. Main Outcome Measure: The European Working Group on Sarcopenia in Older People defines sarcopenia as the presence of both low muscle mass by appendicular skeletal 1 low muscle function by handgrip strength. This study evaluated the clinical and nutritional status (laboratory, anthropometry, dual-energy X-ray absorptiometry, 7-point subjective global assessment) and QoL (Kidney Disease Quality of Life) at baseline. Hospitalization and mortality were recorded during 36 months. Results: Reduced muscle mass was observed in 64% of the patients, reduced muscle strength in 52%, and sarcopenia in 37%. The group with sarcopenia was older, had a higher proportion of men and showed worse clinical and nutritional conditions when compared with patients without sarcopenia. Although reduced muscle mass was strongly associated with poor nutritional status, low muscle strength was associated with worse QoL domains. In the multivariate Cox analyses adjusted by age, gender, dialysis vintage, and diabetes mellitus, low muscle strength alone and sarcopenia were associated with higher hospitalization, and sarcopenia was a predictor of mortality. Conclusion: In conclusion, in this sample, comprised of elderly patients on MHD, sarcopenia was associated with worse nutritional and clinical conditions and was a predictor of hospitalization and mortality. (C) 2017 by the National Kidney Foundation, Inc. All rights reserved.en
dc.description.affiliationUniv Estado Rio De Janeiro, Nutr Inst, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nutr Graduat Program, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nephrol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nutr Graduat Program, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nephrol Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipIDFAPERJ: E-26/111.653/2010
dc.description.sponsorshipIDFAPERJ: E-26/103.209/2011
dc.format.extent197-207
dc.identifierhttp://dx.doi.org/10.1053/j.jrn.2017.12.003
dc.identifier.citationJournal Of Renal Nutrition. Philadelphia, v. 28, n. 3, p. 197-207, 2018.
dc.identifier.doi10.1053/j.jrn.2017.12.003
dc.identifier.issn1051-2276
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55590
dc.identifier.wosWOS:000430406500009
dc.language.isoeng
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofJournal Of Renal Nutrition
dc.rightsAcesso restrito
dc.titleAssociation of Sarcopenia With Nutritional Parameters, Quality of Life, Hospitalization, and Mortality Rates of Elderly Patients on Hemodialysisen
dc.typeArtigo
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