Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

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dc.contributor.authorBaiense, Robson Fantinato [UNIFESP]
dc.contributor.authorAbrahao, Agessandro [UNIFESP]
dc.contributor.authorRicarte, Irapua F. [UNIFESP]
dc.contributor.authorFukuda, Thiago G. [UNIFESP]
dc.contributor.authorOliveira, Ricardo A. [UNIFESP]
dc.contributor.authorSilva, Gisele S. [UNIFESP]
dc.contributor.authorCosta, Maristela
dc.contributor.authorTeixeira, Manoel J.
dc.contributor.institutionHosp Coracao
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:40Z
dc.date.available2016-01-24T14:34:40Z
dc.date.issued2013-11-01
dc.description.abstractAlteplase (recombinant tissue plasminogen activator [rt-PA]) label approval by the Food and Drug Administration remarks the contraindication of its use with known intracranial neoplasm because of potential bleeding complications. Despite this concern, the real risk of intracerebral bleeding in patients with intracranial neoplasms treated with rt-PA is unknown, and there are few reports of thrombolysis in patients with brain tumors. We report a case of a 78-year-old man who was seen in our emergency department within 2 hours from sudden onset of aphasia, right-sided hemiplegia, hypoesthesia, and homonymous hemianopsia. the National Institutes of Health Stroke Scale (NIHSS) score at admission was 20. Intra-arterial thrombolysis was performed with administration of .3 mg/kg of alteplase combined with mechanical thrombectomy. At discharge, his NIHSS score was 1, and after 90 days, his modified Rankin score was 1. To our knowledge, this is the first report of intra-arterial thrombolysis in a patient with acute ischemic stroke with an intracranial tumor.en
dc.description.affiliationHosp Coracao, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, BR-04039000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, BR-04039000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentE658-E660
dc.identifierhttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.05.009
dc.identifier.citationJournal of Stroke & Cerebrovascular Diseases. Amsterdam: Elsevier B.V., v. 22, n. 8, p. E658-E660, 2013.
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2013.05.009
dc.identifier.issn1052-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36946
dc.identifier.wosWOS:000327719000066
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Stroke & Cerebrovascular Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectIntra-arterial thrombolysisen
dc.subjectmeningiomaen
dc.subjectintracranial neoplasmen
dc.subjectacute ischemic strokeen
dc.subjectmechanical thrombectomyen
dc.subjectintracranial hemorrhageen
dc.titleSuccessful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningiomaen
dc.typeinfo:eu-repo/semantics/article
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