Effects of transcutaneous electrical nerve stimulation on fetal and placental development in an experimental model of placental insufficiency

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dc.citation.issue2
dc.citation.volume29
dc.contributor.authorGuimaraes, Camila S. O.
dc.contributor.authorGomes, Bruno B. F.
dc.contributor.authorOliveira, Rafael A.
dc.contributor.authorYamamoto, Leandro R.
dc.contributor.authorRocha, Laura P.
dc.contributor.authorGloria, Maria A. [UNIFESP]
dc.contributor.authorMachado, Juliana R.
dc.contributor.authorCamara, Niels O. S. [UNIFESP]
dc.contributor.authorReis, Marlene A.
dc.contributor.authorCorrea, Rosana R. M.
dc.coverageAbingdon
dc.date.accessioned2020-10-30T18:46:39Z
dc.date.available2020-10-30T18:46:39Z
dc.date.issued2016
dc.description.abstractObjective: To elucidate the effects of transcutaneous electrical nerve stimulation (TENS) in pregnancies with placental insufficiency.Methods: Pregnant rats were subjected to uterine artery ligation and to TENS according to the following groups: ligated stimulated (LS); ligated non-stimulated (LN), control stimulated (CS); and control non-stimulated (CN). Fetal external measurements, such as crown-rump length (CRL), fronto-occipital distance (FOD), thoracic ventral-dorsal (TVDD) and abdominal ventral-dorsal (AVDD) distances were analyzed together with the area occupied by fetal internal organs. Glucose transporter 1 (GLUT-1) expression was evaluated by immunohistochemistry in fetal organs. Thickness of junctional, labyrinth and intermediate placental zones was analyzed by morphometric evaluation in HE-stained slides, and placental hypoxia-inducible factor 1 alfa expression was measured by real-time polymerase chain reaction.Results: In LN and CS groups compared to the CN group, CRL was reduced (27.51/28.95 versus 30.16mm), as well as FOD (6.63/6.63 versus 7.36mm), AVDD (7.38/8.00 versus 8.61mm) and TVDD (6.46/6.87 versus 7.23mm). Brain GLUT-1 expression was higher in LS (1.3%) and CS (1.8%). The area occupied by placental vessels in the labyrinth zone (29.673.51 versus 20.83 +/- 7.63) and intermediate zone (26.46 +/- 10.21 versus 10.86 +/- 8.94) was larger in the LS group than in the LN group.Conclusions: Our results suggest a negative effect of TENS on placental development, thus compromising the maintenance of adequate blood flow to the fetus.en
dc.description.affiliationUniv Fed Triangulo Mineiro, Disciplina Patol Geral, Inst Ciencias Biol & Nat, BR-38025180 Uberaba, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Div Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq - National Counsel of Technological and Scientific Development)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES - Coordination for the Improvement of Higher Education Personnel Foundation)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG - Research Foundation of the State of Minas Gerais)
dc.description.sponsorshipFundacao de Ensino e Pesquisa de Uberaba (FUNEPU - Research Foundation of Uberaba)
dc.format.extent283-289
dc.identifierhttps://doi.org/10.3109/14767058.2014.999034
dc.identifier.citationJournal Of Maternal-Fetal & Neonatal Medicine. Abingdon, v. 29, n. 2, p. 283-289, 2016.
dc.identifier.doi10.3109/14767058.2014.999034
dc.identifier.issn1476-7058
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58550
dc.identifier.wosWOS:000365628300022
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHypoxiaen
dc.subjectIUGRen
dc.subjectperfusionen
dc.subjectplacentaen
dc.subjectpregnancyen
dc.subjectTENSen
dc.titleEffects of transcutaneous electrical nerve stimulation on fetal and placental development in an experimental model of placental insufficiencyen
dc.typeinfo:eu-repo/semantics/article
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