Prospective evaluation of cytokine in saliva of preterm and fullterm neonates

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dc.contributor.authorTalarico Sesso, Maria Lucia
dc.contributor.authorLoureiro Borges, Mariana Castro
dc.contributor.authorLeme Ferriani, Virginia Paes
dc.contributor.authorGeraldo-Martins, Vinicius Range
dc.contributor.authorRocha Rodrigues, Denise Bertulucci
dc.contributor.authorNogueira, Ruchele Dias
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Uberaba
dc.date.accessioned2016-01-24T14:38:05Z
dc.date.available2016-01-24T14:38:05Z
dc.date.issued2014-11-01
dc.description.abstractLittle is known about the ontogeny of the cytokines in saliva of newborn. Previous studies showed that levels of immunoglobulin A (IgA) in saliva could be influenced by prematurity. So, the aim of this study was to analyze the levels of interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and interferon gamma (IFN-gamma) in sample saliva of fullterm (FT) and preterm (PT) neonates at birth (TO) and after 3 months of age (T3). Saliva from 50 infants (25 FT and 25 PT) were collected at TO and T3 and analyzed by Luminex Corporation (Austin, Texas, United States) multiplex assay. Clinical characteristics and social-economic data were assessed through questionnaires. All cytokines could be detected at birth in levels higher than found in T3. the mean levels and frequency of detection of cytokines were significantly higher in PT than FT at TO (P < 0.05). There were a positive association between IL-10 and infection (P < 0.05) and IL-6 and stress (P < 0.005). Salivary cytokines were detected within the first hours after birth and their levels decreased after 3. months. the cytokine levels were different between PT and FT children and appear to be influenced by stress situation and/or antigenic microbial challenge. the results confirm the necessity for further studies about the mucosal immune system by using of saliva as a source of diagnostic by identification of biomarkers of the status of the immune. (C) 2014 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv São Paulo, Med Sch Ribeirao Preto, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv Uberaba, Uberaba, MG, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/57346-5
dc.description.sponsorshipIDFAPESP: 07/50807-7
dc.description.sponsorshipIDCNPq: 472928/2007-4
dc.format.extent830-835
dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2014.07.015
dc.identifier.citationImmunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 219, n. 11, p. 830-835, 2014.
dc.identifier.doi10.1016/j.imbio.2014.07.015
dc.identifier.issn0171-2985
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38397
dc.identifier.wosWOS:000344831700003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofImmunobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCytokinesen
dc.subjectInterferon interleukinsen
dc.subjectImmunoglobulin Aen
dc.subjectPrematurityen
dc.subjectSalivaen
dc.titleProspective evaluation of cytokine in saliva of preterm and fullterm neonatesen
dc.typeinfo:eu-repo/semantics/article
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