Histological analysis of palatopharyngeal muscle from children with snoring and obstructive sleep apnea syndrome

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dc.contributor.authorDe Vuono, Isabela Mattos
dc.contributor.authorZanoteli, Edmar
dc.contributor.authorButte de Oliveira, Acary Souza
dc.contributor.authorFujita, Reginaldo Raimundo
dc.contributor.authorNagata Pignatari, Shirley Shizue
dc.contributor.authorPizarro, Gilberto Ulson
dc.contributor.authorCassia Pradelle-Hallinan, Mrcia Lurdes de
dc.contributor.authorMoreira, Gustavo Antonio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:52Z
dc.date.available2016-01-24T12:41:52Z
dc.date.issued2007-02-01
dc.description.abstractObstructive sleep apnea syndrome (OSAS) is an upper airway obstruction that occurs during the sleep. One of the suggested mechanisms involved in this process is a neuromuscular abnormality of the palatal muscles. Whether children with OSAS develop into OSAS adults, or children and adult OSAS are two distinct disorders occurring at different ages are questions to be answered. Here, we made the histological analysis of palatophryngeat muscle in 34 oral-breathing children of both genders, aged 5-12 years old, with hypertrophic tonsils and adenoids. According to the polysomnographic study the participants were divided into children without sleeping disorders (group I) and children with primary snoring (group II) or apnea (group III). the main histological findings were fiber size variability in 70% cases from groups II and III and in 71% from group I; perimysial connective tissue infiltration in 48% children from groups II and III and in 71% from group I; intracytoplasmatic mitochondrial proliferation in 63% cases from groups II and III and in 57% cases from group I. Muscle necrosis was only observed in one case, in association with subglandular inflammation. Others findings observed in all groups included fibers with internal architecture alteration, such as moth-eaten and lobulated fibers, type 2 fiber predominance, and small areas of fiber type grouping. the presence of similar histological findings in the palatopharyngeal muscle in children with primary snoring or apnea but also in children without sleeping disorders indicate that such changes could be a normal histological feature of this muscle rather than a neurogenic or myopathic pathology. (C) 2006 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Otorhinolaryngol & Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Sleep Med & Biol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Otorhinolaryngol & Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Sleep Med & Biol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent283-290
dc.identifierhttp://dx.doi.org/10.1016/j.ijporl.2006.10.019
dc.identifier.citationInternational Journal of Pediatric Otorhinolaryngology. Clare: Elsevier B.V., v. 71, n. 2, p. 283-290, 2007.
dc.identifier.doi10.1016/j.ijporl.2006.10.019
dc.identifier.issn0165-5876
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29494
dc.identifier.wosWOS:000244018300013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectsleep disordersen
dc.subjectpalatopharyngeal muscleen
dc.subjectmuscle histologyen
dc.subjectsoft palateen
dc.subjectsnoringen
dc.titleHistological analysis of palatopharyngeal muscle from children with snoring and obstructive sleep apnea syndromeen
dc.typeinfo:eu-repo/semantics/article
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