Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study

Página do item simplificado
dc.citation.issue3
dc.citation.volume11
dc.contributor.authorPesaro, Antonio Eduardo P.
dc.contributor.authorKatz, Marcelo
dc.contributor.authorKatz, Jason N.
dc.contributor.authorValente Barbas, Carmen Silvia
dc.contributor.authorMakdisse, Marcia R.
dc.contributor.authorCorrea, Alessandra G.
dc.contributor.authorFranken, Marcelo
dc.contributor.authorPereira, Carolina
dc.contributor.authorSerrano, Carlos V., Jr.
dc.contributor.authorLopes, Renato D. [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-08-21T16:59:52Z
dc.date.available2020-08-21T16:59:52Z
dc.date.issued2016
dc.description.abstractPurpose Patients with acute myocardial infarction (AMI) and respiratory impairment may be treated with either invasive or non-invasive mechanical ventilation (MV). However, there has been little testing of non-invasive MV in the setting of AMI. Our objective was to evaluate the incidence and associated clinical outcomes of patients with AMI who were treated with noninvasive or invasive MV. Methods This was a retrospective observational study in which consecutive patients with AMI (n = 1610) were enrolled. The association between exclusively non-invasive MV, invasive MV and outcomes was assessed by multivariable models. Results Mechanical ventilation was used in 293 patients (54% invasive and 46% exclusively noninvasive). In-hospital mortality rates for patients without MV, with exclusively non-invasive MV, and with invasive MV were 4.0%, 8.8%, and 39.5%, respectively (P<0.001). The median lengths of hospital stay were 6 (5.8-6.2), 13 (11.2-4.7), and 28 (18.0-37.9) days, respectively (P<0.001). Exclusively non-invasive MV was not associated with in-hospital death (adjusted HR = 0.90, 95% CI 0.40-1.99, P = 0.79). Invasive MV was strongly associated with a higher risk of in-hospital death (adjusted HR = 3.07, 95% CI 1.79-5.26, P<0.001). Conclusions In AMI setting, 18% of the patients required MV. Almost half of these patients were treated with exclusively non-invasive strategies with a favorable prognosis, while patients who needed to be treated invasively had a three-fold increase in the risk of death. Future prospective randomized trials are needed to compare the effectiveness of invasive and non-invasive MV for the initial approach of respiratory failure in AMI patients.en
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
dc.description.affiliationUniv N Carolina, Div Cardiol, Chapel Hill, NC USA
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Pulm, Heart Inst INCOR, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Heart Inst INCOR, Sao Paulo, Brazil
dc.description.affiliationDuke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Sch Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0151302
dc.identifier.citationPlos One. San Francisco, v. 11, n. 3, p. -, 2016.
dc.identifier.doi10.1371/journal.pone.0151302
dc.identifier.fileWOS000372572800057.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57786
dc.identifier.wosWOS:000372572800057
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Studyen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000372572800057.pdf
Tamanho:
318.94 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos