Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method

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dc.contributor.authorSuchecki, D.
dc.contributor.authorPalma, B. D.
dc.contributor.authorTufik, S.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:09Z
dc.date.available2016-01-24T12:31:09Z
dc.date.issued2000-09-01
dc.description.abstractThe objective of the present study was to assess the sleep rebound of animals exposed to the modified multiple platform method (MMPM), in which cage-mate rats were placed onto narrow platforms (NP=6.5 cm in diameter), onto wide platforms (WP=14 cm in diameter) or onto a grid (GR). the last two groups were included as environmental controls for the deprivation method. Animals were implanted with bipolar electrodes in the cortex, hippocampus and neck muscle. Baseline sleep was recorded for 6 h, after which the animals were placed in one of the above-mentioned settings for 90 h and their sleep was again recorded. Comparison between baseline and post-GR recordings revealed no sleep differences in these animals. Placement of animals onto WP resulted in augmented sleep time (16%), time spent in PS (+99%), duration of PS episodes (+77%), sleep efficiency (+16%), and in reduced latency to PS (-84.8%). Finally, NP animals exhibited a dramatic increase in Sleep time (+34.3%), time spent in PS (+184.7%), duration of PS episodes (+106%), and in sleep efficiency (+34.4%). Moreover, sleep latency (-52.2%) and time spent in SWS (-12.2%) were reduced. Based on the results of sleep rebound, the data indicated that placement of animals onto narrow platforms in the MMPM was an effective PS deprivation method and the grid should be considered as an adequate environmental control. (C) 2000 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent14-22
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(00)02531-2
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 875, n. 1-2, p. 14-22, 2000.
dc.identifier.doi10.1016/S0006-8993(00)02531-2
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26371
dc.identifier.wosWOS:000089199300002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPS deprivationen
dc.subjectmethodologyen
dc.subjectmodified multiple platform method polysomnographyen
dc.titleSleep rebound in animals deprived of paradoxical sleep by the modified multiple platform methoden
dc.typeinfo:eu-repo/semantics/article
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