Effect of long-term type 1 diabetes on renal sodium and water transporters in rats

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dc.contributor.authorVidotti, Daniela B. [UNIFESP]
dc.contributor.authorArnoni, Carine P. [UNIFESP]
dc.contributor.authorMaquigussa, Edgar [UNIFESP]
dc.contributor.authorBoim, Mirian A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:27Z
dc.date.available2016-01-24T13:49:27Z
dc.date.issued2008-01-01
dc.description.abstractThe effects of long-term diabetes in the presence of established nephropathy on tubular function remains poorly understood. We evaluated the levels of the main sodium and water transport proteins expressed in the kidney after long-term (8 weeks) of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in untreated (D) and insulin (4 U/s.c./day)-treated (D+I) rats. D animals presented upregulation (similar to 4.5-fold) of Na/ glucose cotransporter (SGLT1), whereas the alpha-subunit of the epithelial sodium channel (alpha-ENaC) and aquaporin 1 (AQP1) were downregulated (similar to 20 and 30% respectively) with no change in the Na/H exchanger (NHE3), Na/Cl cotransporter (TSC) and AQP2. Insulin replacement partially prevented these alterations and caused increases in the expression of alpha-ENaC and AQP2. These effects suggest an action of insulin in the tubular transport properties. the upregulation of SGLT1 may constitute a mechanism to prevent greater glucose losses in the urine but it may result in glucotoxicity to the proximal epithelial cells contributing to the diabetic nephropathy. the decrease of alpha-ENaC in D animals may compensate for the increased sodium reabsorption via SGLT1 resulting in discrete natriuresis. DM-induced polyuria was not due to changes in AQP2 expression. Copyright (c) 2007 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent107-114
dc.identifierhttp://dx.doi.org/10.1159/000109967
dc.identifier.citationAmerican Journal of Nephrology. Basel: Karger, v. 28, n. 1, p. 107-114, 2008.
dc.identifier.doi10.1159/000109967
dc.identifier.issn0250-8095
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30350
dc.identifier.wosWOS:000251048600014
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofAmerican Journal of Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectdiabetic nephropathyen
dc.subjectsodium transportersen
dc.subjectrenal tubulesen
dc.subjectaquaporinsen
dc.subjectinsulinen
dc.titleEffect of long-term type 1 diabetes on renal sodium and water transporters in ratsen
dc.typeinfo:eu-repo/semantics/article
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