The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis

dc.contributor.authorArganaraz, Gustavo Adolfo [UNIFESP]
dc.contributor.authorKonno, Ana Carla [UNIFESP]
dc.contributor.authorPerosa, Sandra Regina [UNIFESP]
dc.contributor.authorSantiago, Joselita Ferreira Carvalho [UNIFESP]
dc.contributor.authorBoim, Mirian A. [UNIFESP]
dc.contributor.authorVidotti, Daniela Berguio [UNIFESP]
dc.contributor.authorVarella, Pedro Paulo Vasconcellos [UNIFESP]
dc.contributor.authorCosta, Luciana Gilbert [UNIFESP]
dc.contributor.authorCanzian, Mauro
dc.contributor.authorPorcionatto, Marimelia Aparecida [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorSakamoto, Americo Ceiki [UNIFESP]
dc.contributor.authorCarrete, Henrique [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorAmado, Debora [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorSilva, Jose Antonio
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNove Julho Univ
dc.date.accessioned2016-01-24T13:51:34Z
dc.date.available2016-01-24T13:51:34Z
dc.date.issued2008-08-01
dc.description.abstractPurpose: As reported by several authors, angiotensin II (AngII) is a proinflammatory molecule that stimulates the release of inflammatory cytokines and activates nuclear factor kappa B (NF kappa B), being also associated with the increase of cellular oxidative stress. Its production depends on the activity of the angiotensin converting enzyme (ACE) that hydrolyzes the inactive precursor angiotensin I (AngI) into AngII. It has been suggested that AngII underlies the physiopathological mechanisms of several brain disorders such as stroke, bipolar disorder, schizophrenia, and disease. the aim of the present work was to localize and quantify AngII AT1 and AT2 receptors in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis (MTS) submitted to corticoamygdalohippocampectomy for seizure control.Method: Immunohistochemistry, Western blot, and real-time PCR techniques were employed to analyze the expression of these receptors.Results: the results showed an upregulation of AngII AT1 receptor as well as its messenger ribonucleic acid (mRNA) expression in the cortex and hippocampus of patients with MTS. in addition, an increased immunoexpression of AngII AT2 receptors was found only in the hippocampus of these patients with no changes in its mRNA levels.Discussion: These data show, for the first time, changes in components of renin-angiotensin system (RAS) that could be implicated in the physiopathology of MTS.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurgery, Discipline Expt Neurol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurgery, Discipline Nephrol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Clin Neurol, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Clin Neurol, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationNove Julho Univ, Dept Sci Rehabil, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurgery, Discipline Expt Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurgery, Discipline Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Clin Neurol, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Clin Neurol, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1348-1357
dc.identifierhttp://dx.doi.org/10.1111/j.1528-1167.2008.01581.x
dc.identifier.citationEpilepsia. Oxford: Blackwell Publishing, v. 49, n. 8, p. 1348-1357, 2008.
dc.identifier.doi10.1111/j.1528-1167.2008.01581.x
dc.identifier.issn0013-9580
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30809
dc.identifier.wosWOS:000257988300008
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofEpilepsia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectangiotensin II AT1 and AT2 receptorsen
dc.subjecttemporal lobe epilepsyen
dc.subjectcortexen
dc.subjecthippocampusen
dc.titleThe renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosisen
dc.typeinfo:eu-repo/semantics/article
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