Characterization of Rabbit Corneas Subjected to Stromal Stiffening by the Acai Extract (Euterpe oleracea)

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dc.citation.issue4
dc.citation.volume42
dc.contributor.authorBersanetti, Patricia A. [UNIFESP]
dc.contributor.authorBueno, Tatiane L. N. [UNIFESP]
dc.contributor.authorMorandim-Giannetti, Andreia de A.
dc.contributor.authorNogueira, Regina F. [UNIFESP]
dc.contributor.authorMatos, Jivaldo R.
dc.contributor.authorSchor, Paulo [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-17T14:02:27Z
dc.date.available2020-07-17T14:02:27Z
dc.date.issued2017
dc.description.abstractPurpose: In this study, we characterized rabbit corneas subjected to corneal cross-linking (CXL) with acai extract compared with a riboflavin photo-stimulated procedure. Materials and Methods: The corneas of the slaughterhouse rabbits were divided into three groups: control, consisting of untreated corneal samplesen
dc.description.abstractriboflavin/UVA, where corneas were treated with 0.1% riboflavin photo-stimulated at 365 nm as the standard protocolen
dc.description.abstractand acai, where the samples were subjected to 4% acai extract for 0.5-2 h. After the CXL procedure, corneas of the three groups were characterized by analyzing their elastic modulus and thermal denaturation profile. Results: The elastic modulus at 3% strain showed an approximately threefold increase in the riboflavin/UVA group and 10.5 times in the corneas treated with 4% acai extract for 2 h, compared with the control group (p < 0.01). The denaturation temperature values of the two groups of crosslinked corneas increased significantly (p < 0.05) and were more pronounced in the acai group. Conclusions: The acai extract was effective in promoting CXL in rabbit corneas as characterized by the different techniques.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Informat Saude, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, Sao Bernardo Do Campo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Informat Saude, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipIDFAPESP: 2013/20857-3
dc.description.sponsorshipIDFAPESP: 2012/07343-8
dc.format.extent528-533
dc.identifierhttp://dx.doi.org/10.1080/02713683.2016.1214970
dc.identifier.citationCurrent Eye Research. Philadelphia, v. 42, n. 4, p. 528-533, 2017.
dc.identifier.doi10.1080/02713683.2016.1214970
dc.identifier.issn0271-3683
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54821
dc.identifier.wosWOS:000399609900006
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCurrent Eye Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAcai extracten
dc.subjectcorneal crosslinkingen
dc.subjectdifferential scanning calorimetryen
dc.subjectelastic modulusen
dc.subjectkeratoconusen
dc.subjectriboflavinen
dc.titleCharacterization of Rabbit Corneas Subjected to Stromal Stiffening by the Acai Extract (Euterpe oleracea)en
dc.typeinfo:eu-repo/semantics/article
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