DNA and histone methylation in gastric carcinogenesis

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dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.date.accessioned2016-01-24T14:31:16Z
dc.date.available2016-01-24T14:31:16Z
dc.date.issued2013-02-28
dc.description.abstractEpigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. (C) 2013 Baishideng. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Lab Human Cytogenet, Inst Biol Sci, BR-66075110 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2009/07145-9
dc.description.sponsorshipIDFAPESP: 2010/11174-1
dc.format.extent1182-1192
dc.identifierhttp://dx.doi.org/10.3748/wjg.v19.i8.1182
dc.identifier.citationWorld Journal of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 19, n. 8, p. 1182-1192, 2013.
dc.identifier.doi10.3748/wjg.v19.i8.1182
dc.identifier.issn1007-9327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35986
dc.identifier.wosWOS:000315521700005
dc.language.isoeng
dc.publisherBaishideng Publishing Group Inc
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpigeneticen
dc.subjectDNA methylationen
dc.subjectHistone methylationen
dc.subjectGastric canceren
dc.subjectGastric carcinogenesisen
dc.titleDNA and histone methylation in gastric carcinogenesisen
dc.typeinfo:eu-repo/semantics/article
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