Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease
Nenhuma Miniatura disponível
Data
2018
Autores
Santos-Lobato, Bruno Lopes
Borges, Vanderci [UNIFESP]
Ferraz, Henrique Ballalai [UNIFESP]
Mata, Ignacio Fernandez
Zabetian, Cyrus P.
Tumas, Vitor
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background: Levodopa-induced dyskinesia (LID) is a common complication of advanced Parkinson's disease (PD). PD physiopathology is associated with dopaminergic and non-dopaminergic pathways, including the nitric oxide system. The present study aims to examine the association of a neuronal nitric oxide synthase gene (NOS1) single nucleotide polymorphism (rs2682826) with LID in PD patients. Methods and results: We studied 186 PD patients using levodopa. The presence of LID was defined as a MDS-UPDRS Part IV score >= 1 on item 4.1. We tested for association between NOS1 rs2682826 and the presence, daily frequency, and functional impact of LID using regression models, adjusting for important covariates. There was no significant association between genotype and any of the LID-related variables examined. Conclusions: Our results suggest that this NOS1 polymorphism does not contribute to LID susceptibility or severity. However, additional studies that include a comprehensive set of NOS1 variants will be needed to fully define the role of this gene in LID. (C) 2017 Elsevier Inc. All rights reserved.
Descrição
Citação
Nitric Oxide-Biology And Chemistry. San Diego, v. 74, p. 86-90, 2018.