In Vitro and In Vivo Toxicology Evaluation to Determine Suitable Biomedical Polymers for Development of a Papain-Containing Drug Delivery System
Lopes, Patricia Santos [UNIFESP]
Alcântara, Mara Tãnia Silva
Velasco, Maria Valéria Robles
Miyamaru, Ligia Luriko
Bárbara, Maria Cristina Santa
Rogero, Sizue Ota
Lugao, Ademar Benevolo
Mathor, Monica Beatriz
Is part ofLatin American Journal Of Pharmacy
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Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap papain into a polymeric matrix to provide an adequate drug delivery system consists of an alternative to this problem. The purpose of this study was to assess in vitro and in vivo four polymers cytotoxicity and ability to cause cutaneous irritation to be applied as a suitable papain delivery system. A Monocomponent (MSD) and Bicomponent Silicone Dispersions (BSD) and, Natural Rubber Bicentrifuged Latex (NRBL) and an Acrylic Adhesive (AA) were selected. The cytotoxicity was firstly assessed by the Neutral Red Uptake Method. Non-cytotoxic polymers were then submitted to in vivo Cutaneous Irritation Test. Both silicone dispersions were found non-cytotoxic, and NRBL and AA polymers showed cytotoxicity. MSD and BSD polymers did not cause any cutaneous reactions.
CitationLatin American Journal Of Pharmacy. La Plata: Colegio Farmaceuticos Provincia De Buenos Aires, v. 30, n. 6, p. 1104-1108, 2011.
SponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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