ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN THE PRESSOR-RESPONSE TO STIMULATION OF THE NUCLEUS-RAPHE-OBSCURUS
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Data
1993-06-01
Autores
Campos, Ruy Ribeiro [UNIFESP]
Futuroneto, H. A.
Guertzenstein, Pedro Gaspar [UNIFESP]
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1. Electrical stimulation of the nucleus raphe obscurus (NRO) in urethane-anesthetized rats increases arterial blood pressure (BP) between 20 and 95 mmHg (mean, 61.14 +/- 6.57; N = 30).2. Unilateral electrolytic destruction of the rostral ventrolateral medulla (RVLM) did not reduce BP or heart rate (HR) but significantly reduced the pressor response to NRO stimulation (control, DELTA 76.0 +/- 5.4 mmHg; after lesion, DELTA 26.0 +/- 13.9 mmHg; P<0.01, N = 5).3. Bilateral destruction of the RVLM reduced basal BP (control, 104.1 +/- 11.4 mmHg; after lesion, 58.0 +/- 5.7 mmHg; P<0.01) and the pressor response to NRO stimulation (control, DELTA 71.6 +/- 7.3; after lesion, DELTA 12.5 +/- 3.8 mmHg; P<0.01, N = 6).4. When topically applied to or microinjected into the RVLM, pentobarbital sodium (200 nl/l mul, 10 nmol) decreased BP, HR and the pressor response to NRO stimulation (control, DELTA 56.2 +/-6.7 mmHg; after pentobarbital, DELTA 11.2 +/- 3.1 mmHg; P<0.01, N = 13). Similar effects were obtained when glycine (200 nl, 50 nmol) was microinjected into RVLM (control, DELTA 40.5 +/- 5.9 mmHg; after glycine, DELTA 18.1 +/- 4.9 mmHg; P<0.01, N = 6).5. We conclude that RVLM is essential for the pressor response to NRO stimulation.
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Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 26, n. 6, p. 623-631, 1993.