Mechanical dysfunction in the mucosal oedema formation of patients with nasal polyps
Nenhuma Miniatura disponível
Data
2014-06-01
Autores
Pezato, Rogerio [UNIFESP]
Voegels, Richard Louis
Pinto Bezerra, Thiago Freire
Perez-Novo, Claudina
Stamm, Aldo Cassol [UNIFESP]
Gregório, Luiz Carlos [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background: Nasal polyposis (NP) is characterized by an anomalous tissue growth with oedema and a lack of extracellular matrix. in this study, we investigated whether a mechanical disfunction of the forces that act in oedema formation is present in NP.Methods: We compared the interstitial hydrostatic pressure behaviour during a saline solution infusion between healthy nasal mucosa (inferior and middle turbinate from 10 patients) and inflamed nasal mucosa from NP patients (inferior, middle turbinate and a nasal polyp from 6 patients). We used Controlled Disc Stimulation equipment to compare the curve Pressure/Volume created during the saline solution infusion.Results:The pressure at 0.2 ml infusion was lower in the middle turbinate of NP patients than in the middle turbinate of control patients. the lowest P/V mean assessed was in the polypoid tissue.Conclusions: the interstitial hydrostatic pressure showed different behaviour during liquid infusion in nasal mucosa from NP patients when compared with healthy nasal mucosa. This study allows us to cogitate on a new pathophysiological mechanism contributing to the development of the NP.
Descrição
Citação
Rhinology. Utrecht: Int Rhinologic Soc, v. 52, n. 2, p. 162-166, 2014.