Effects of acute and long-term typical or atypical neuroleptics on morphine-induced behavioural effects in mice
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2014-03-01
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Hollais, Andre W. [UNIFESP]
Patti, Camilla L. [UNIFESP]
Zanin, Karina A. [UNIFESP]
Fukushiro, Daniela F. [UNIFESP]
Berro, Lais F. [UNIFESP]
Carvalho, Rita C. [UNIFESP]
Kameda, Sonia R. [UNIFESP]
Frussa-Filho, Roberto [UNIFESP]
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<list list-type=1 id=cep12203-list-0001> It has been suggested that the high prevalence of drug abuse in schizophrenics is related to chronic treatment with typical neuroleptics and dopaminergic supersensitivity that develops as a consequence. Within this context, atypical neuroleptics do not seem to induce this phenomenon. in the present study, we investigated the effects of acute administration or withdrawal from long-term administration of haloperidol and/or ziprasidone on morphine-induced open-field behaviour in mice. in the first experiment, mice were given a single injection of haloperidol (1mg/kg, i.p.) or several doses of ziprasidone (2, 4 or 6mg/kg, i.p.) and motor activity was quantified by the open-field test. the aim of the second experiment was to verify the effects of an acute injection of haloperidol (1mg/kg) or ziprasidone (6mg/kg) on 20mg/kg morphine-induced behaviours in the open-field test. in the third experiment, mice were treated with 1mg/kg haloperidol and/or 2, 4 or 6mg/kg ziprasidone for 20days. Seventy-two hours after the last injection, mice were injected with 20mg/kg, i.p., morphine and then subjected to the open-field test. Acute haloperidol or ziprasidone decreased spontaneous general activity and abolished morphine-induced locomotor stimulation. Withdrawal from haloperidol or ziprasidone did not modify morphine-elicited behaviours in the open-field test. the results suggest that withdrawal from neuroleptic treatments does not contribute to the acute effect of morphine in schizophrenic patients.
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Clinical and Experimental Pharmacology and Physiology. Hoboken: Wiley-Blackwell, v. 41, n. 3, p. 255-263, 2014.