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dc.contributor.authorValois, Fabricio Martins [UNIFESP]
dc.contributor.authorNery, Luiz Eduardo [UNIFESP]
dc.contributor.authorRamos, Roberta Pulcheri [UNIFESP]
dc.contributor.authorFerreira, Eloara Vieira Machado [UNIFESP]
dc.contributor.authorSilva, Celia Camelo [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.contributor.authorOta-Arakaki, Jaquelina Sonoe [UNIFESP]
dc.date.accessioned2016-01-24T14:35:18Z
dc.date.available2016-01-24T14:35:18Z
dc.date.issued2014-02-03
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0087699
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 2, 6 p., 2014.
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37426
dc.description.abstractIt has been reported that schistosomiasis-associated PAH (Sch-PAH) has a more benign clinical course compared with idiopathic PAH (IPAH). We therefore hypothesized that Sch-PAH subjects would present with less impaired cardiopulmonary and metabolic responses to exercise than IPAH patients, even with similar resting pulmonary hemodynamic abnormalities. the aim of this study was to contrast physiologic responses to incremental exercise on cycle ergometer between subjects with Sch-PAH and IPAH. We performed incremental cardiopulmonary exercise tests (CPET) in subjects newly diagnosed with IPAH (n = 9) and Sch-PAH (n = 8), within 1 month of the hemodynamic study and before the initiation of specific therapy for PAH. There were no significant between-group differences in cardiac index, pulmonary vascular resistance or mean pulmonary artery pressure. However, mean peak oxygen uptake (VO2) was greater in Sch-PAH than IPAH patients (75.5 +/- 21.4 vs 54.1 +/- 16.1% predicted, p = 0.016), as well as the ratio of increase in VO2 to work rate (8.1 +/- 1.0 vs 6.8 +/- 1.8 mL/min/W, p = 0.03). Additionally, the slope of the ventilatory response as a function of CO2 output was lower in Sch-PAH (40.3 +/- 3.9 vs 55.6 +/- 19.8; p = 0.04), and the heart rate response for a given change in VO2 was also diminished in Sch-PAH compared to IPAH (80.1 +/- 20.6 vs 123.0 +/- 39.2 beats/L/min; p = 0.02). in conclusion, Sch-PAH patients had less impaired physiological responses to exercise than IPAH subjects with similar resting hemodynamic dysfunction. Our data suggest a more preserved cardiopulmonary response to exercise in Sch-PAH which might be related to its better clinical course compared to IPAH.en
dc.format.extent6
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleContrasting Cardiopulmonary Responses to Incremental Exercise in Patients with Schistosomiasis-Associated and Idiopathic Pulmonary Arterial Hypertension with Similar Resting Hemodynamic Impairmenten
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionQueens Univ
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Med, Div Resp Dis, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationQueens Univ, Dept Med, Div Resp & Crit Care Med, Kingston, ON K7L 3N6, Canada
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Med, Div Resp Dis, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Med, Div Cardiol, São Paulo, Brazil
dc.identifier.fileWOS000330626900102.pdf
dc.identifier.doi10.1371/journal.pone.0087699
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000330626900102


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