WAIST CIRCUMFERENCE AS A PREDICTOR of ADIPONECTIN LEVELS in PERITONEAL DIALYSIS PATIENTS: A 12-MONTH FOLLOW-UP STUDY
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2013-03-01
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Bazanelli, Ana Paula [UNIFESP]
Kamimura, Maria Ayako [UNIFESP]
Canziani, Maria Eugênia Fernandes [UNIFESP]
Manfredi, Silvia Regina [UNIFESP]
Cuppari, Lilian [UNIFESP]
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Objectives: This prospective study, conducted at the dialysis unit of the Nephrology Division, Federal University of São Paulo-Oswaldo Ramos Foundation, Brazil, aimed to evaluate whether waist circumference (WC) can predict adiponectin levels in patients undergoing peritoneal dialysis (PD).Methods: Among 115 patients on PD at a single dialysis center who were evaluated at 6 and 12 months, 57% were men, 31% had diabetes, mean age was 52.8 +/- 16.1 years, body mass index was 25 +/- 4.3 kg/m(2), and dialysis vintage was 13 months (range: 5 - 33 months). We measured WC at the umbilicus level. Adiponectin was determined by an enzyme-linked immunosorbent assay.Results: At baseline, WC was inversely associated with adiponectin (r = -0.48, p < 0.01). After adjustment for sex, age, diabetes, peritoneal clearance, and residual renal function, WC was an independent determinant of serum adiponectin (beta = -0.52; 95% confidence interval: -0.73 to -0.31; p < 0.001). in the prospective analysis, after adjustment for confounders, changes in WC predicted changes in adiponectin. for each unit increase in WC, adiponectin declined by 0.39 mg/L (p < 0.001).Conclusions: This study demonstrates that WC is associated with adiponectin and, more importantly, that this simple marker of central adiposity was able to predict changes in adiponectin levels over time. Perit Dial Int 2013; 33(2):182-188 www.PDIConnect.com epub ahead of print: 01 Sep 2012 doi:10.3747/pdi.2011.00129
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Peritoneal Dialysis International. Toronto: Multimed Inc, v. 33, n. 2, p. 182-188, 2013.