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dc.contributor.authorFurtado, Guilherme H. [UNIFESP]
dc.contributor.authorNicolau, David P.
dc.identifier.citationExpert Opinion On Therapeutic Patents. London: Informa Healthcare, v. 20, n. 10, p. 1273-1276, 2010.
dc.description.abstractThe rapidly escalating prevalence of antimicrobial resistance is a global concern. This reduced susceptibility to currently available antimicrobial agents coupled with the progressive shortage of newly approved compounds is a worrisome situation. Major problems are encountered for a growing number of Gram-positive (i.e., Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus spp.) and Gram-negative pathogens (i.e., Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae). We provide an overview of bacterial resistance focusing on the most common pathogens responsible for infection in both the community and healthcare settings. in addition, several strategies to curb antimicrobial resistance are also discussed. It is increasingly evident that without the introduction of novel antimicrobial agents, a return to the clinical outcomes associated with the pre-antibiotic era are inevitable.en
dc.publisherInforma Healthcare
dc.relation.ispartofExpert Opinion On Therapeutic Patents
dc.rightsAcesso restrito
dc.subjectantibacterial agentsen
dc.subjectdrug resistanceen
dc.subjectGram-negative bacteriaen
dc.subjectGram-positive coccien
dc.titleOverview perspective of bacterial resistanceen
dc.contributor.institutionHartford Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationHartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06102 USA
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo Hosp, São Paulo, Brazil
dc.description.affiliationHartford Hosp, Div Infect Dis, Hartford, CT 06115 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo Hosp, São Paulo, Brazil
dc.description.sourceWeb of Science

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