ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas
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2009-06-01
Autores
Burim, Regislaine Valeria
Teixeira, Silvia Aparecida
Colli, Benedicto Oscar
Peria, Fernanda Maris
Tirapelli, Luis Fernando
Nagahashi Marie, Suely Kazue
Fleury Malheiros, Suzana Maria [UNIFESP]
Oba-Shinjo, Sueli Mieko
Gabbai, Alberto Alain [UNIFESP]
Lotufo, Paulo Andrade
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Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. the aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. the distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.
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Clinical and Experimental Medicine. New York: Springer, v. 9, n. 2, p. 157-163, 2009.