T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals
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2007-04-01
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Iwai, Leo Kei
Yoshida, Marcia
Sadahiro, Aya
Silva, Washington Robert da
Marin, Maria Lucia
Goldberg, Anna Carla
Juliano, Maria Aparecida
Juliano, Luiz
Shikanai-Yasuda, Maria Aparecida
Kalil, Jorge
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Vaccines with synthetic peptides induce the immune response to epitopes that bind to several RLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.
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Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 14, n. 4, p. 474-476, 2007.