An open randomized study comparing immunosuppression therapy initiated before or after kidney transplantation in haploidentical living recipients
Nenhuma Miniatura disponível
Data
2004-08-01
Autores
Camara, NOS
Dias, MFL
Pacheco-Silva, A.
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background: Acute rejection is the most important risk factor for graft survival. Although many centers start immunosuppressive therapy days before the surgery in living donors, there is no systematic study concerning the possible advantages of this procedure. in this open randomized study, we compared the efficacy and safety of administration of cyclosporine (CSA; Neoral((R))) and azathioprine before renal transplantation with the administration of the same schema after transplantation, in HLA haploidentical grafts.Methods: Sixty renal transplant recipients of an HLA haploidentical allograft from living donors were randomized in two groups: (A) patients that started immunosuppression 3 d before transplantation (n = 30) and (B) those who started the drug schema on the first day after surgery (n = 30). We analyzed the incidence and severity of acute rejection, graft function and infection during the first 3 months after transplantation.Results: the group of patients who started immunosuppression before had a mean trough level of CSA (299.70 +/- 154.03 ng/mL) in the expected range for an efficacious prevention of acute rejection at the surgery day. Thirteen patients (43.3%) in each group had acute rejection during the follow up (p = 1.00). Two grafts losses (3.3%) occurred, one in each group. Both groups had similar 3-month rejection-free graft survival (56.7 and 56.3%). the incidence of infection was also statistical comparable between groups A and B (56.7 vs. 46.7, p = 0.430). Graft function was similar in patients from both groups.Conclusions: Pre-transplant administration of immunosuppression did not reduce the incidence or severity of acute rejection episodes during the first 3 months of transplantation. Immunosuppressive drugs administered before engraftment did not increase the incidence of graft dysfunction or infection.
Descrição
Citação
Clinical Transplantation. Copenhagen: Blackwell Munksgaard, v. 18, n. 4, p. 450-455, 2004.