C-13-urea breath test to diagnose Helicobacter pylori infection in children aged up to 6 years
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Data
2004-01-01
Autores
Machado, R. S.
Patricio, FRD
Kawakami, E.
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Artigo
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Background. C-13-urea breath test (C-13-UBT) is an accurate noninvasive tool for diagnosis of Helicobacter pylori infection. It is considered the best method for epidemiological studies, but there are few studies to evaluate the C-13-UBT in infants and toddlers.Aim. To evaluate the C-13-UBT performed with infrared spectroscopy in children aged up to 6 years.Patients. Sixty-eight patients (6 months. to 5 years 11 months.) were evaluated prospectively and consecutively.Methods. Helicobacter pylori infection was detected by positive culture, or rapid urease test and histological examination, both positive. C-13-UBT was performed with 50 mg of C-13-urea diluted in 100 ml of commercial orange juice. Two expired air samples were collected: before and 30 minutes after tracer ingestion. Cutoff of delta over baseline (DOB) was 4.0parts per thousand and urea hydrolysis rate 10 mug/minute. Results. Fifteen of 68 (22.1%) patients were H. pylori infected. Sensitivity was 93.3% (95% Cl; 86.8%-99.7%) and specificity was 96.2% (95% CI; 93.6%-98.8%), and these values were equal for DOB and urea hydrolysis rate. Negative DOB values in noninfected patients ranged from -1.5parts per thousand to 2.6parts per thousand and positive DOB values ranged from 10.8parts per thousand. to 105.5parts per thousand. There was no relationship between DOB values and age.Conclusion. C-13-UBT performed with infrared spectroscopy proved to be a reliable and accurate noninvasive diagnostic tool for H. pylori infection detection in children aged up to 6 years. Results far from cutoff value can clearly distinguish positive from negative C-13-UBT results in children up to 6 years old.
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Helicobacter. Malden: Wiley-Blackwell, v. 9, n. 1, p. 39-45, 2004.