Monoclonality of asynchronous bilateral lymphoma of the testis

Monoclonality of asynchronous bilateral lymphoma of the testis

Author Leite, KRM Google Scholar
Garicochea, B. Google Scholar
Srougi, M. Google Scholar
Dzik, C. Google Scholar
Nesralhah, L. Google Scholar
Moura, R. P. de Google Scholar
Simpson, AJG Google Scholar
Darini, E. Google Scholar
Carvalho, C. M. Google Scholar
Camara-Lopes, L. H. Google Scholar
Institution Sirio Libanes Hosp
Universidade Federal de São Paulo (UNIFESP)
Hosp A C Camargo
Abstract Objectives: Lymphoma is the most frequent testicular malignancy in men over 60 years of age. Even though patients present initially with localized disease, the high incidence of bilateral involvement, synchronous or not, and early systemic dissemination are characteristic of these neoplasms. Sometimes the interval between tumor involvement of both testes is long. the question is raised whether either the patient has a predisposition to present new clones of transformed lymphocytes, or the same disease using the same pathway from a systemic reservoir infiltrates the contralateral testis.Method: Polymerase chain reaction and DNA sequencing were used to detect immunoglobulin heavy chain (IgH) rearrangement in paraffin-embedded specimens from asynchronous tumors affecting the right and left testis of a 85-year-old man with an interval period of 13 months.Results: Both tumors showed the same IgH rearrangement.Conclusions.. the lymphoma affecting the left and right testis derived from the same clone. It makes a strong case that lymphoma of the testis is the first manifestation of a systemic disease and should be treated aggressively early at the beginning of the disease. Copyright (C) 2000 S. Karger AG. Basel.
Keywords testis
malignant lymphoma
gene rearrangements
B lymphocyte
heavy chain
polymerase chain reaction
Language English
Date 2000-12-01
Published in European Urology. Basel: Karger, v. 38, n. 6, p. 774-777, 2000.
ISSN 0302-2838 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 774-777
Access rights Closed access
Type Article
Web of Science ID WOS:000165692800029

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